ArticleScientific reports2017
Temporal dynamics of cerebellar and motor cortex physiological processes during motor skill learning.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Cerebellar transcranial magnetic stimulation for improving balance capacity and activity of daily living in stroke patients: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Effects of Cerebellar tACS With Gamma Band on Basketball Shooting Skills: A Single-Blind, Randomized Controlled Trial in College Students With Basketball Experience.Brain and behavior · 2025Trial
- The use of transcranial direct current stimulation to facilitate motor skill reactivations of a choice reaction time task in adults.Physiological reports · 2025Trial
- Variant Target Effects on Motor Learning With M1 Anodal tDCS.Brain and behavior · 2025Trial
- The Effect of taVNS on the Cerebello-Thalamo-Cortical Pathway: a TMS Study.Cerebellum (London, England) · 2024Trial
- Trial
- Long-Term Application of Cerebellar Transcranial Direct Current Stimulation Does Not Improve Motor Learning in Parkinson's Disease.Cerebellum (London, England) · 2022Trial
- Modulation of human primary motor cortex plasticity during proactive and retroactive interference between motor practice and paired associative stimulation.Experimental brain research · 2026Article
- Cerebellar Transcranial Direct Current Stimulation Induces a Predominant Motor Rather than Perceptive Contribution to Emotion Facial Expression Processing.Brain sciences · 2026Article
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.Scientific reports · 2026Article
- M1 a-tDCS does not acutely enhance motor skill acquisition of a dexterous, timing-based videogame task in adults.Physiological reports · 2026Article
- Concurrent Bilateral M1 and Anodal Cerebellar tDCS Effects on Learning of a Bimanual Video Game Task.Brain and behavior · 2025Article
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar Brain Inhibition and Its Association with Motor Inhibition and Reaction Time In Younger and Older Adults.Cerebellum (London, England) · 2025Article
- Modulation of primary motor cortex after experimentally induced and use-dependent plasticity in young and older adults.Experimental brain research · 2025Article
- Article
- The effects of football juggling learning on executive function and brain functional connectivity.Frontiers in human neuroscience · 2024Article
- Cerebellar Transcranial Direct Current Stimulation Applied over Multiple Days Does Not Enhance Motor Learning of a Complex Overhand Throwing Task in Young Adults.Bioengineering (Basel, Switzerland) · 2023Article
- Investigating Cerebellar Modulation of Premovement Beta-Band Activity during Motor Adaptation.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Learning motor tasks involves distinct physiological processes in the cerebellum (CB) and primary motor cortex (M1). Previous studies have shown that motor learning results in at least two important neurophysiological changes: modulation of cerebellar output mediated in-part by long-term depression of parallel fiber-Purkinje cell synapse and induction of long-term plasticity (LTP) in M1, leading to transient occlusion of additional LTP-like plasticity. However, little is known about the temporal dynamics of these two physiological mechanisms during motor skill learning. Here we use non-invasive brain stimulation to explore CB and M1 mechanisms during early and late motor skill learning in humans. We predicted that early skill acquisition would be proportional to cerebellar excitability (CBI) changes, whereas later stages of learning will result in M1 LTP-like plasticity modifications. We found that early, and not late into skill training, CBI changed. Whereas, occlusion of LTP-like plasticity over M1 occurred only during late, but not early training. These findings indicate a distinct temporal dissociation in the physiological role of the CB and M1 when learning a novel skill. Understanding the role and temporal dynamics of different brain regions during motor learning is critical to device optimal interventions to augment learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.