ArticleScientific reports2017
Photoacoustic pump-probe tomography of fluorophores in vivo using interleaved image acquisition for motion suppression.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Temporally delayed, dual-pulse, dual-wavelength photoacoustic imaging (TD-DP-DW-PAI): advancing capabilities of a commercial light-emitting diode-based photoacoustic imaging system with a pulsed laser diode.Biomedical optics express · 2025Article
- Photo-thermoresponsive polypyrrole-crosslinked single-chain nanoparticles for photothermal therapy.Communications chemistry · 2025Article
- Controlling the sound of light: photoswitching optoacoustic imaging.Nature methods · 2024Review
- Interleave-sampled photoacoustic imaging: a doubled and equivalent sampling rate for high-frequency imaging.Optics letters · 2022Article
- [Progress of motion artifact correction in photoacoustic microscopy and photoacoustic tomography].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Fluorescent and Water Dispersible Single-Chain Nanoparticles: Core-Shell Structured Compartmentation.Angewandte Chemie (International ed. in English) · 2021Article
- Synchronously Amplified Photoacoustic Image Recovery (SAPhIRe).Photoacoustics · 2020Article
- A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties.Journal of the American Chemical Society · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fluorophores, the excited state lifetime can be modulated using pump-probe excitation. By generating photoacoustic (PA) signals using simultaneous and time-delayed pump and probe excitation pulses at fluences below the maximum permissible exposure, a modulation of the signal amplitude is observed in fluorophores but not in endogenous chromophores. This provides a highly specific contrast mechanism that can be used to recover the location of the fluorophore using difference imaging. The practical challenges in applying this method to in vivo PA tomography include the typically low concentrations of fluorescent contrast agents, and tissue motion. The former results in smaller PA signal amplitudes compared to those measured in blood, while the latter gives rise to difference image artefacts that compromise the unambiguous and potentially noise-limited detection of fluorescent contrast agents. To address this limitation, a method based on interleaved pump-probe image acquisition was developed. It relies on fast switching between simultaneous and time-delayed pump-probe excitation to acquire PA difference signals in quick succession, and to minimise the effects of tissue motion. The feasibility of this method is demonstrated in tissue phantoms and in initial experiments in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.