ArticleScientific reports2017
Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis.International journal of molecular sciences · 2023Pooled it
- Progress in multi-omics studies of osteoarthritis.Biomarker research · 2025Review
- Proteomics appending a complementary dimension to precision oncotherapy.Computational and structural biotechnology journal · 2024Review
- Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet's disease uveitis.BMC ophthalmology · 2024Article
- Recent progress in mass spectrometry-based urinary proteomics.Clinical proteomics · 2024Review
- Psoriasis to Psoriatic Arthritis: The Application of Proteomics Technologies.Frontiers in medicine · 2021Review
- Bile and urine peptide marker profiles: access keys to molecular pathways and biological processes in cholangiocarcinoma.Journal of biomedical science · 2020Article
- Bioinformatic Analysis of the Wound Peptidome Reveals Potential Biomarkers and Antimicrobial Peptides.Frontiers in immunology · 2020Article
- Proteomics and phosphoproteomics in precision medicine: applications and challenges.Briefings in bioinformatics · 2019Review
- Proteomic profiling of urine: implications for lupus nephritis.Expert review of proteomics · 2019Review
- Clinical Features of Psoriatic Arthritis: a Comprehensive Review of Unmet Clinical Needs.Clinical reviews in allergy & immunology · 2018Review
- Recent Advances in the Etiopathogenesis of Inflammatory Bowel Disease: The Role of Omics.Molecular diagnosis & therapy · 2018Review
- Current concepts and unmet needs in psoriatic arthritis.Clinical rheumatology · 2018Review
- Review
- Molecular Network Analysis of the Urinary Proteome of Alzheimer's Disease Patients.Dementia and geriatric cognitive disorders extraArticle
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Authors and funding
10 authors.
Funding
Abstract
Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions. Herein we explored whether urinary proteomic biomarkers specific for different forms of arthritis (rheumatoid arthritis (RA), psoriatic arthritis (PsA), osteoarthritis (OA)) or chronic inflammatory conditions (inflammatory bowel disease (IBD)) can be identified. Fifty subjects per group with RA, PsA, OA or IBD and 50 healthy controls were included in the study. Two-thirds of these populations were randomly selected to serve as a training set, while the remaining one-third was reserved for validation. Sequential comparison of one group to the other four enabled identification of multiple urinary peptides significantly associated with discrete pathological conditions. Classifiers for the five groups were developed and subsequently tested blind in the validation test set. Upon unblinding, the classifiers demonstrated excellent performance, with an area under the curve between 0.90 and 0.97 per group. Identification of the peptide markers pointed to dysregulation of collagen synthesis and inflammation, but also novel inflammatory markers. We conclude that urinary peptide signatures can reliably differentiate between chronic arthropathies and inflammatory conditions with discrete pathogenesis.
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