Evidence map›Paper›PMID 28091514›Full record

ArticleScientific reports2017

Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.

Laura Cracco, Silvio Notari, Ignazio Cali, Man-Sun Sy, Shu G Chen, Mark L Cohen, Bernardino Ghetti, Brian S Appleby, Wen-Quan Zou, Byron Caughey and 2 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Laura CraccoDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Silvio NotariDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Ignazio CaliDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Man-Sun SyDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Shu G ChenDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Mark L CohenDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Division of Neuropathology, Indiana University, Indianapolis, Indiana, United States of America.
Brian S ApplebyDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Wen-Quan ZouDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Byron CaugheyLaboratory of Persistent Viral Diseases, NIH/NIAID Rocky Mountain Laboratories, Hamilton, Montana, United States of America.
Jiri G SafarDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Pierluigi GambettiDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
Case Western Reserve University · USIndiana University – Purdue University Indianapolis · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Structures and Activities of Prions and Prion Proteins ZIAAI000580 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$8.9M
Neuropathology Core - P GambettiP01AI106705 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI · 2014 to 2018
$7.7M
Structural correlates of prion strain, phenotype and infectivity in human prion dR01NS083687 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI, SUREWICZ, WITOLD K · 2014 to 2018
$2.9M
NCEZID CDC HHS U51 CK000100NIAID NIH HHS P01 AI106705NIA NIH HHS P30 AG010133NINDS NIH HHS R01 NS083687
6 · The paper itself

Abstract

In most human sporadic prion diseases the phenotype is consistently associated with specific pairings of the genotype at codon 129 of the prion protein gene and conformational properties of the scrapie PrP (PrP

Indexed as

Creutzfeldt-Jakob SyndromeGenotypeGlycosylationHumansInsomnia, Fatal FamilialPhenotypePrion DiseasesPrion ProteinsPrionsPrPSc ProteinsPrion ProteinsPrionsPrPSc Proteins

Identifiers

PMID28091514
PMCPMC5238384
OpenAlexW2578596437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.