ArticleJournal of enzyme inhibition and medicinal chemistry2017
Carbonic anhydrase from Apis mellifera: purification and inhibition by pesticides.
Article in Journal of enzyme inhibition and medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- The Role of Cytochrome P450 4C1 and Carbonic Anhydrase 3 in Response to Temperature Stress inInsects · 2021Article
- Investigation of pesticides on honey bee carbonic anhydrase inhibition.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development.International journal of molecular sciences · 2020Review
- New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Design, synthesis, and characterization of 2,2-bis(2,4-dinitrophenyl)-2-(phosphonatomethylamino)acetate as a herbicidal and biological active agent.Journal of chemical biology · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbonic anhydrase (CA) enzymes have been shown to play an important role in ion transport and in pH regulation in several organisms. Despite this information and the wealth of knowledge regarding the significance of CA enzymes, few studies have been reported about bee CA enzymes and the hazardous effects of chemicals. Using Apis mellifera as a model, this study aimed to determine the risk of pesticides on Apis mellifera Carbonic anhydrase enzyme (Am CA). CA was initially purified from Apis mellifera spermatheca for the first time in the literature. The enzyme was purified with an overall purification of ∼35-fold with a molecular weight of ∼32 kDa. The enzyme was then exposed to pesticides, including tebuconazole, propoxur, carbaryl, carbofuran, simazine and atrazine. The six pesticides dose-dependently inhibited in vitro AmCA activity at low micromolar concentrations. IC
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