ArticleMagnetic resonance in medicine2017
Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- Evaluation of 0.55T MRI for Simultaneous R2* and Fat Fraction Quantification in the Presence of Hepatic Iron Overload and Steatosis Using Simulations and Phantoms.Magnetic resonance in medicine · 2026Article
- Impact of particle size onMagnetic resonance in medicine · 2025Article
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- Computed Tomography and Magnetic Resonance Imaging in Liver Iron Overload: From Precise Quantification to Prognosis Assessment.Biomedicines · 2024Review
- Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024Review
- Simulation of a virtual liver iron overload model and RNMR in biomedicine · 2023Article
- Quantitative MRI of diffuse liver diseases: techniques and tissue-mimicking phantoms.Magma (New York, N.Y.) · 2023Review
- QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023Review
- High-resolution 3D ultra-short echo time MRI with Rosette k-space pattern for brain iron content mapping.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023Article
- Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.Radiology · 2023Review
- Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Biopsy-based optimization and calibration of a signal-intensity-ratio-based MRI method (1.5 Tesla) in a dextran-iron loaded mini-pig model, enabling estimation of very high liver iron concentrations.Magma (New York, N.Y.) · 2022Article
- Assessment of iron nanoparticle distribution in mouse models using ultrashort-echo-time MRI.NMR in biomedicine · 2022Article
- Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated RJournal of magnetic resonance imaging : JMRI · 2022Article
- 3 T: the good, the bad and the ugly.The British journal of radiology · 2022Review
- Free-breathingMagnetic resonance in medicine · 2021Article
- Complex confounder-corrected R2* mapping for liver iron quantification with MRI.European radiology · 2021Article
- A hybrid (iron-fat-water) phantom for liver iron overload quantification in the presence of contaminating fat using magnetic resonance imaging.Magma (New York, N.Y.) · 2020Article
- Characterizing a short TMagnetic resonance in medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
purposeHepatic iron content (HIC) quantification via transverse relaxation rate (R2*)-MRI using multi-gradient echo (mGRE) imaging is compromised toward high HIC or at higher fields due to the rapid signal decay. Our study aims at presenting an optimized 2D ultrashort echo time (UTE) sequence for R2* quantification to overcome these limitations.
methodsTwo-dimensional UTE imaging was realized via half-pulse excitation and radial center-out sampling. The sequence includes chemically selective saturation pulses to reduce streaking artifacts from subcutaneous fat, and spatial saturation (sSAT) bands to suppress out-of-slice signals. The sequence employs interleaved multi-echo readout trains to achieve dense temporal sampling of rapid signal decays. Evaluation was done at 1.5 Tesla (T) and 3T in phantoms, and clinical applicability was demonstrated in five patients with biopsy-confirmed massively high HIC levels (>25 mg Fe/g dry weight liver tissue).
resultsIn phantoms, the sSAT pulses were found to remove out-of-slice contamination, and R2* results were in excellent agreement to reference mGRE R2* results (slope of linear regression: 1.02/1.00 for 1.5/3T). UTE-based R2* quantification in patients with massive iron overload proved successful at both field strengths and was consistent with biopsy HIC values.
conclusionThe UTE sequence provides a means to measure R2* in patients with massive iron overload, both at 1.5T and 3T. Magn Reson Med 78:1839-1851, 2017. © 2017 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.