ArticleScience advances2016
Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase.
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Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
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34 citing papers in PubMed, 44 citations in OpenAlex.
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- Spatiotemporal characterization of single-stranded DNA intermediates after UV irradiation: II. Rapid growth and effects of recA and recJ.PLoS genetics · 2026Article
- Transcription-replication collisions trigger high-fidelity replication reset.Nucleic acids research · 2025Article
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- Hallmarks of DNA replication stress responses in Escherichia coli and Bacillus subtilis.FEMS microbiology reviews · 2025Review
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- Life, the genome and everything.Journal of bacteriology · 2023Article
- Generation and Repair of Postreplication Gaps in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2023Review
- RecF protein targeting to post-replication (daughter strand) gaps II: RecF interaction with replisomes.Nucleic acids research · 2023Article
- Rapid profiling of DNA replication dynamics using mass spectrometry-based analysis of nascent DNA.The Journal of cell biology · 2023Article
- Chromosome Segregation and Cell Division Defects inMicroorganisms · 2023Article
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- Interactions of small molecules with DNA junctions.Nucleic acids research · 2022Review
- Host nucleases generate prespacers for primed adaptation in theScience advances · 2022Article
- DNA Holliday Junction: History, Regulation and Bioactivity.International journal of molecular sciences · 2022Review
- Single strand gap repair: The presynaptic phase plays a pivotal role in modulating lesion tolerance pathways.PLoS genetics · 2022Article
- Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing.Nature communications · 2022Article
- Modulation of RecFORQ- and RecA-Mediated Homologous Recombination in Escherichia coli by Isoforms of Translation Initiation Factor IF2.Journal of bacteriology · 2022Article
- The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Jun XiaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-7331-0673
Li-Tzu ChenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Qian MeiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX 77030, USA.
Chien-Hui MaDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.; Institute of Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA.ORCID 0000-0001-8753-8556
Jennifer A HallidayDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Hsin-Yu LinDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
David MagnanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9506-8857
John P PribisDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9267-6715
Devon M FitzgeraldDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2480-7269
Holly M HamiltonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Megan RichtersDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Ralf B NehringDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Xi ShenDepartment of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Lei LiDepartment of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
David BatesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
P J HastingsDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Christophe HermanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Makkuni JayaramDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.; Institute of Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA.
Susan M RosenbergDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX 77030, USA.
Baylor College of Medicine · USThe University of Texas at Austin · USThe University of Texas MD Anderson Cancer Center · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3MVirology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LEWIS, DOROTHY E. · 1994 to 2015
$21.7MTRANSGENIC MOUSE MODELS TO STUDY OVARIAN FUNCTIONU54HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI RICHARDS, JOANNE STEWART · 1998 to 2013
$19.9MMolecular Noise, Transcription Errors and Heritable Phenotypic ChangeR01GM088653 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI HERMAN, CHRISTOPHE · 2010 to 2019
$3.1MMUTATIONAL SIGNATURE(S) OF HUMAN GENOMIC REARRANGEMENT MECHANISMSR01GM106373 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI HASTINGS, PHILIP JOHN, LUPSKI, JAMES R. · 2014 to 2022
$3.1MGROWTH AND DIFFERENTIATION IN EUKARYOTEST32HD007495 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KINTNER, CHRISTOPHER ROBERT · 1995 to 2009
$1.6MDynamics and regulation of sister chromosome cohesion in E. coli.R01GM102679 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BATES, DAVID · 2012 to 2016
$1.5MForward Genomics of Damage Control: An Undiscovered Class of Cancer GenesDP1CA174424 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2012 to 2013
$1.5MGenetic Framework and Molecular Mechanism of Fanconi AnemiaR01CA190635 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, LEI · 2015 to 2018
$1.5MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kTRANSGENIC ANIMAL--COREP30HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GLASSER, STANLEY R · 1985 to 1997
–NCI NIH HHS DP1 CA174424NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA190635NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NICHD NIH HHS P30 HD007495NICHD NIH HHS T32 HD007495NICHD NIH HHS U54 HD007495NIDDK NIH HHS P30 DK056338NIGMS NIH HHS R01 GM088653NIGMS NIH HHS R01 GM102679NIGMS NIH HHS R01 GM106373
Abstract
DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. However, the main kinds and sources of DNA damage repaired by HR in somatic cells and the roles of important HR proteins remain elusive. We present engineered proteins that trap, map, and quantify Holliday junctions (HJs), a central DNA intermediate in HR, based on catalytically deficient mutant RuvC protein of
Indexed as
DNA, BacterialDNA Breaks, Single-StrandedDNA, CruciformEscherichia coliRecombination, GeneticRecQ HelicasesDNA, NeoplasmHumansNeoplasm ProteinsNeoplasmsRad51 RecombinaseDNA, BacterialDNA, CruciformDNA, NeoplasmNeoplasm ProteinsRAD51 protein, humanRad51 RecombinaseRecQ HelicasesRECQL4 protein, humanRecQ protein, E coliBLMcancerDNA repairDNA replicationEscherichia coliholliday junctionshomologous recombinationRecQ family proteinsRuvCspontaneous DNA damage
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