Evidence map›Paper›PMID 28090561›Full record

ReviewCellular and molecular gastroenterology and hepatology2016

Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum.

Sasirekha Ramani, Liya Hu, B V Venkataram Prasad, Mary K Estes

Open access · goldAbstract readReview
In one paragraph

Review in Cellular and molecular gastroenterology and hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sasirekha RamaniDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.
Liya HuVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas.
B V Venkataram PrasadVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas.
Mary K EstesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.
Baylor College of Medicine · US

Funding

Structural Studies on RotavirusesR37AI036040 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI PRASAD, BIDADI VENKATARAM · 2003 to 2022
$10.9M
Regulation of Rotavirus ReplicationR01AI080656 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Sue Ellen Crawford, Mary Kolb Estes · 2009 to 2026
$7.9M
STRUCTURAL STUDIES ON ROTAVIRUSESR01AI036040 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Bidadi Venkataram Prasad · 1994 to 2026
$4.3M
NIAID NIH HHS R01 AI036040NIAID NIH HHS R01 AI080656NIAID NIH HHS R37 AI036040
6 · The paper itself

Abstract

Interaction with cellular glycans is a critical initial step in the pathogenesis of many infectious agents. Technological advances in glycobiology have expanded the repertoire of studies delineating host glycan-pathogen interactions. For rotavirus, the VP8* domain of the outer capsid spike protein VP4 is known to interact with cellular glycans. Sialic acid was considered the key cellular attachment factor for rotaviruses for decades. Although this is true for many rotavirus strains causing infections in animals, glycan array screens show that many human rotavirus strains bind nonsialylated glycoconjugates, called

Indexed as

GlcNAc, N-acetylglucosamineGlycansHBGA, histo-blood group antigenHIE, human intestinal enteroidHisto-Blood Group AntigensLacNAc, N-acetyllactosamineLe, LewisLNnT, lacto-N-neotetraoseLNT, lacto-N-tetraoseNeu5Ac, N-acetylneuraminic acidNeu5Gc, N-glycolylneuraminic acidNMR, nuclear magnetic resonanceRBC, red blood cellRotavirusSiaSia, sialic acidVP8*VP, viral protein

Identifiers

PMID28090561
PMCPMC5042371
OpenAlexW2295949104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.