Evidence map›Paper›PMID 28090537›Full record

ArticleBioMed research international2016

Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China.

Yang Song, Zhenwu Du, Ming Ren, Qiwei Yang, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Jincheng Wang, Guizhen Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yang SongDepartment of Orthopedics, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China; Engineering Research Center of Molecular Diagnosis and Cellular Treatment for Metabolic Bone Diseases in Jilin Province, Ziqiang Street 218, Changchun 130041, China.
Zhenwu DuDepartment of Orthopedics, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China; Engineering Research Center of Molecular Diagnosis and Cellular Treatment for Metabolic Bone Diseases in Jilin Province, Ziqiang Street 218, Changchun 130041, China; Research Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.ORCID 0000-0003-0342-0353
Ming RenDepartment of Orthopedics, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China; Engineering Research Center of Molecular Diagnosis and Cellular Treatment for Metabolic Bone Diseases in Jilin Province, Ziqiang Street 218, Changchun 130041, China.
Qiwei YangResearch Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.
Yujie SuiResearch Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.
Qingyu WangResearch Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.
Ao WangDepartment of Orthopedics, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.
Haiyue ZhaoResearch Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.
Jincheng WangDepartment of Orthopedics, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China; Engineering Research Center of Molecular Diagnosis and Cellular Treatment for Metabolic Bone Diseases in Jilin Province, Ziqiang Street 218, Changchun 130041, China.ORCID 0000-0002-1217-5962
Guizhen ZhangDepartment of Orthopedics, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China; Engineering Research Center of Molecular Diagnosis and Cellular Treatment for Metabolic Bone Diseases in Jilin Province, Ziqiang Street 218, Changchun 130041, China; Research Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130041, China.ORCID 0000-0003-1313-8001
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex determining region Y-box 9 (SOX9) is a key transcription factor involved in cartilage formation during the embryonic development stage and cartilage growth and repair after birth. To explore the roles of polymorphism and expression of the SOX9 gene in the development of osteonecrosis of the femoral head (ONFH), we analyzed the polymorphism of rs12601701 [A/G] and rs1042667 [A/C] and the serum protein expression of the SOX9 gene in 182 patients with ONFH and 179 healthy control subjects. Results revealed that the A-A haplotype of SOX9 gene as well as the GG and AA genotypes of rs12601701 was significantly associated with increased ONFH risk (

Indexed as

Gene Expression RegulationPolymorphism, GeneticSOX9 Transcription FactorAdultAgedAsian PeopleChinaFemaleFemur Head NecrosisHumansMaleMiddle AgedRisk FactorsSOX9 protein, humanSOX9 Transcription Factor

Identifiers

PMID28090537
PMCPMC5174161
OpenAlexW2560599231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.