Evidence map›Paper›PMID 28090518›Full record

ArticleAnnals of translational medicine2016

Clinical characteristics and molecular pathology of skull ectopic thyroid cancer.

Longxing Cao, Zhongyong Wang, Jiawei Ma, Jinsheng Chen, Haojiang Zhu, Xiaohua Zhou, Qing Zhu, Jun Dong, Qing Lan, Qiang Huang

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Longxing CaoDepartment of Neurosurgery, The Third People's Hospital of Zhangjiagang, Zhangjiagang 215611, China.
Zhongyong WangDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Jiawei MaDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Jinsheng ChenDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Haojiang ZhuDepartment of Neurosurgery, Guanghe Chinese & Western Medicine Hospital, Zhangjiagang 215633, China.
Xiaohua ZhouDepartment of Neurosurgery, Guanghe Chinese & Western Medicine Hospital, Zhangjiagang 215633, China.
Qing ZhuDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Jun DongDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Qing LanDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Qiang HuangDepartment of Neurosurgery, The 2nd Affiliated Hospital of Soochow University, Suzhou 215004, China.
Soochow University · CNZhangjiagang First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid cancer is very common, but skull ectopic thyroid cancer has not been reported in 50 years of literatures in foreign countries. There are only four cases of the skull ectopic thyroid cancer reported in more than 30 years of domestic literature including the cases in this report. This paper aims to investigate the clinical characteristics and possible molecular mechanisms of this rare disease. Five keywords of "thyroid gland", "ectopic thyroid", "thyroid cancer", "ectopic thyroid cancer" and "metastatic thyroid cancer" were included and 50 years of literatures in the PubMed-MEDLINE and Wanfang database were reviewed. By combining the test data of 2 cases of surgical patient tissue microarray specimens-molecular immunology pathology, the possible molecular mechanisms were analyzed and molecular regulation network diagram was drawn. The skull ectopic thyroid cancer has not been reported in 50 years of literatures in foreign countries and there are only four cases of the skull ectopic thyroid cancer reported in more than 30 years of domestic literature including the cases in this report. The molecular expressions of skull ectopic thyroid cancer, orthotopic thyroid cancer, and metastatic thyroid cancer were not the same: (I) AKT (P=0.012, 0.002) and mTOR (P=0.002, 0.004) were highly expressed in the skull ectopic thyroid cancer; (II) BRAF (P=0.029, 0.014) and ERK (P=0.002, 0.001) were highly expressed in orthotopic thyroid cancer; (III) MMP-9 (P=0.023, 0.016) was highly expressed in metastatic thyroid cancer. According to the molecular information base, the

Indexed as

Ectopic thyroidectopic thyroid carcinomametastatic thyroid carcinomamolecular pathwaythyroid carcinoma

Identifiers

PMID28090518
PMCPMC5220041
OpenAlexW2567089736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.