Evidence map›Paper›PMID 28090487›Full record

ArticleBlood research2016

Clinical characteristics and outcomes of varicella zoster virus infection in children with hematologic malignancies in the acyclovir era.

Seul-Ki Kim, Min Chae Kim, Seung Beom Han, Seong Koo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang, Hack-Ki Kim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Seul-Ki KimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Min Chae KimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seung Beom HanDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seong Koo KimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae Wook LeeDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Nack-Gyun ChungDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Bin ChoDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dae Chul JeongDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jin Han KangDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hack-Ki KimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV infection in the acyclovir era have rarely been reported.

methodsThe medical records of children diagnosed with varicella or herpes zoster virus, who had underlying hematologic malignancies, were retrospectively reviewed, and the clinical characteristics and outcomes of VZV infection were evaluated.

resultsSeventy-six episodes of VZV infection (herpes zoster in 57 and varicella in 19) were identified in 73 children. The median age of children with VZV infection was 11 years (range, 1-17), and 35 (46.1%) episodes occurred in boys. Acute lymphoblastic leukemia was the most common underlying malignancy (57.9%), and 90.8% of the episodes occurred during complete remission of the underlying malignancy. Acyclovir was administered for a median of 10 days (range, 4-97). Severe VZV infection occurred in 16 (21.1%) episodes. Although the finding was not statistically significant, a previous history of hematopoietic cell transplantation (HCT) appeared to be associated with the development of more severe episodes of herpes zoster (

conclusionClinical characteristics of VZV infection in immunocompromised children were not significantly different from those without it, and clinical outcomes improved after the introduction of acyclovir therapy. However, risk factors for severe VZV infection require further investigation in a larger population and a prospective setting.

Indexed as

ChildLeukemiaLymphomaVaricella zoster virus

Identifiers

PMID28090487
PMCPMC5234238
OpenAlexW2568609727

What OpenQuestion holds

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.