ArticleClinical and experimental reproductive medicine2016
Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months.
Article in Clinical and experimental reproductive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- A systematic review and Bayesian analysis of the adverse effects of dienogest.BMC pharmacology & toxicology · 2024Pooled it
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure.Human reproduction update · 2020Pooled it
- The clinical outcome of Dienogest treatment followed by in vitro fertilization and embryo transfer in infertile women with endometriosis.Journal of ovarian research · 2019Trial
- Three-dimensional patient-derived endometriosis model for drug evaluation.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Single-cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis-associated mesothelial cells (EAMCs) and ectopic stromal cells may influence progesterone resistance.Clinical and translational medicine · 2025Article
- Case Report: Long-term maintenance of GnRH-a combined with dienogest for thoracic endometriosis syndrome.Frontiers in medicine · 2025Article
- Risk factors and countermeasures for abnormal uterine bleeding during dienogest therapy for adenomyosis: a review.Frontiers in reproductive health · 2025Review
- Dienogest in endometriosis treatment: A narrative literature review.Clinical and experimental reproductive medicine · 2023Article
- Thoracic endometriosis masquerading as Meigs' syndrome in a young woman: A case report and literature review.Case reports in women's health · 2022Article
- Impact of Long-Term Dienogest Therapy on Quality of Life in Asian Women with Endometriosis: the Prospective Non-Interventional Study ENVISIOeN.Reproductive sciences (Thousand Oaks, Calif.) · 2022Observational
- Clinical Efficacy of Dienogest versus Levonorgestrel-Releasing Intrauterine System for Adenomyosis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Real world data on symptomology and diagnostic approaches of 27,840 women living with endometriosis.Scientific reports · 2021Observational
- Role of Dienogest in Endometriosis in Young Women.Journal of obstetrics and gynaecology of India · 2021Article
- Article
- Safety of Dienogest and Other Hormonal Treatments for Endometriosis in Real-World Clinical Practice (VIPOS): A Large Noninterventional Study.Advances in therapy · 2020Observational
- Significant risk factors for malignant transformation of ovarian endometrioma during dienogest treatment: a case report and retrospective study.Journal of medical case reports · 2019Article
- Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma.Obstetrics & gynecology science · 2018Article
- Gastrointestinal and Urinary Tract Endometriosis: A Review on the Commonest Locations of Extrapelvic Endometriosis.Advances in medicine · 2018Review
- Meta-Analysis of Chinese Traditional Medicine Bushen Huoxue Prescription for Endometriosis Treatment.Evidence-based complementary and alternative medicine : eCAM · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy and safety of dienogest treatment in patients who had received dienogest for 12 months or more to treat endometriosis.
methodsWe analyzed the clinical data of 188 women with endometriosis who had been treated with 2 mg of dienogest once a day for 12 months or more at a single institute. We evaluated changes in endometriosis-associated pain and endometrioma size, recurrence rate, and adverse events following dienogest administration. Bone mineral density (BMD) was measured in patients who were prescribed dienogest for more than 18 months.
resultsPain was significantly reduced at 12 months after dienogest medication. In those treated with dienogest due to recurrent endometrioma, the size of the endometrioma was significantly decreased at the 12-month and 18-month follow-ups. We found only one case of sonographic recurrence during dienogest administration among those who were treated postoperatively to prevent recurrence (1 of 114, 0.9%). The most common adverse drug reaction was uterine bleeding (3.2%), and other adverse events were generally tolerable and associated with low discontinuation rates (5.2%). Among the 50 patients in whom BMD was measured, 10 patients (20%) had a Z-score below the expected range for age.
conclusionThe administration of dienogest for a year or more seems to be highly effective in preventing recurrence after surgery, reducing endometriosis-associated pain, and decreasing the size of recurrent endometrioma, with a favorable safety and tolerability profile. However, BMD should be checked in patients on long-term medication due to possible bone loss in some women.
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