ArticleClinical and experimental reproductive medicine2016
Glucose-6-phosphate dehydrogenase deficiency does not increase the susceptibility of sperm to oxidative stress induced by H
Article in Clinical and experimental reproductive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Apigeninidin-enrichedExperimental biology and medicine (Maywood, N.J.) · 2022Article
- Erythrocyte and spermatozoa glucose-6-phosphate dehydrogenase activity in merino rams: An experimental study.International journal of reproductive biomedicine · 2018Article
- Deficiency of peroxiredoxin 6 or inhibition of its phospholipase AScientific reports · 2017Article
- Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen.American journal of men's healthArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGlucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect. G6PD plays a key role in the pentose phosphate pathway, which is a major source of nicotinamide adenine dinucleotide phosphate (NADPH). NADPH provides the reducing equivalents for oxidation-reduction reductions involved in protecting against the toxicity of reactive oxygen species such as H
methodsSemen samples were obtained from four males with G6PD deficiency and eight healthy males as a control. In both groups, motile sperms were isolated from the seminal fluid and incubated with 0, 10, 20, 40, 60, 80, and 120 µM concentrations of H
resultsIncubation of sperms with 10 and 20 µM H
conclusionG6PD deficiency does not increase the susceptibility of sperm to oxidative stress induced by H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.