ArticleJournal of clinical & translational endocrinology2015
Hormone therapy in transgender adults is safe with provider supervision; A review of hormone therapy sequelae for transgender individuals.
Article in Journal of clinical & translational endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Biochemical liver damage during gender affirming therapy in trans adults assigned female at birth: a meta-analysis.Journal of endocrinological investigation · 2025Pooled it
- How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation.British journal of sports medicine · 2021Pooled it
- Breaking barriers: navigating cardiovascular health in the transgender community.Internal and emergency medicine · 2026Review
- Endocrine issues in critically ill transgender patients: A narrative review.World journal of critical care medicine · 2025Review
- Prolactinoma Resection in a Transgender Woman on Gender-affirming Hormone Therapy.JCEM case reports · 2025Article
- Body modification technologies and transvestite and trans people in Argentina: A quantitative study on inequalities in use and access.Salud colectiva · 2025Observational
- Case Report: Ischemic stroke in a young transgender woman due to unsupervised estrogen therapy.Frontiers in global women's health · 2025Article
- Inflammation as a Potential Mechanism Contributing to Sexual Functioning Following Initiation of Gender-Affirming Hormone Therapy.Current sexual health reports · 2024Article
- Effect of GnRH Active Immunisation on Reproductive Performance of Male Sprague Dawley Rats.International journal of molecular sciences · 2024Article
- "Ever since I knew I was trans I knew I wanted hormone therapy": a qualitative exploration into the journey of Australian trans individuals accessing feminizing gender-affirming hormone therapy.International journal of transgender health · 2024Article
- Use of hormones and risk of venous thromboembolism.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- A Qualitative Examination of Tobacco Use and Smoking Cessation Among Gender Minority Adults.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Glucose Homeostasis, Diabetes Mellitus, and Gender-Affirming Treatment.Biomedicines · 2023Review
- Liver function in transgender persons: Challenges in the COVID-19 era.World journal of clinical cases · 2023Review
- Effects of Hormones on Breast Development and Breast Cancer Risk in Transgender Women.Cancers · 2022Review
- Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health.Current heart failure reports · 2022Review
- Use of Hormones Among Trans Women in the West Coast of Peninsular Malaysia: A Mixed Methods Study.Transgender health · 2022Article
- The Real-World Characteristics of Gender-Affirming Hormonal Use Among Transgender People in Thailand.Sexual medicine · 2022Article
- Venous thromboembolism in transgender women.Jornal vascular brasileiro · 2022Article
- Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.International journal of transgender health · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionSome providers report concern for the safety of transgender hormone therapy (HT).
methodsThis is a systematic literature review of HT safety for transgender adults.
resultsCurrent literature suggests HT is safe when followed carefully for certain risks. The greatest health concern for HT in transgender women is venous thromboembolism. HT among transgender men appears to cause polycythemia. Both groups experienced elevated fasting glucose. There is no increase in cancer prevalence or mortality due to transgender HT.
conclusionAlthough current data support the safety of transgender HT with physician supervision, larger, long-term studies are needed in transgender medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.