Evidence map›Paper›PMID 28090432›Full record

ArticleCurrent transplantation reports2016

Update on Chronic Lung Allograft Dysfunction.

Jason M Gauthier, Ramsey R Hachem, Daniel Kreisel

Abstract read
In one paragraph

Article in Current transplantation reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Donor-derived cell-free DNA associated with increased risk of chronic lung allograft dysfunction and mortality: Are absolute levels better than percentage?The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Transplant Trial Watch.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Oscillometry of the respiratory system: a translational opportunity not to be missed.American journal of physiology. Lung cellular and molecular physiology · 2021
    Review
  16. Article
  17. Pediatric lung transplantation: Dynamics of the microbiome and bronchiolitis obliterans in cystic fibrosis.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2020
    Observational
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jason M GauthierDepartment of Surgery, Washington University in St. Louis, Saint Louis, MO.
Ramsey R HachemDepartment of Medicine, Washington University in St. Louis, Saint Louis, MO.
Daniel KreiselDepartment of Surgery, Washington University in St. Louis, Saint Louis, MO ; Department of Pathology & Immunology, Washington University in St. Louis, Saint Louis, MO.

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Wenjun Li · 2015 to 2026
$19.4M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
BASIC SCIENCE RESEARCH TRAINING: CARDIOPULMONARY SURGERYT32HL007776 · NHLBI · WASHINGTON UNIVERSITY · PI DAMIANO, RALPH J · 1994 to 2020
$4.6M
MECHANISMS OF LUNG ALLOGRAFT ACCEPTANCER01HL113931 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, KRUPNICK, ALEXANDER S. · 2012 to 2015
$1.5M
NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL113931NIAID NIH HHS P01 AI116501
6 · The paper itself

Abstract

Chronic lung allograft dysfunction (CLAD) encompasses a range of pathologies that cause a transplanted lung to not achieve or maintain normal function. CLAD manifests as airflow restriction and/or obstruction and is predominantly a result of chronic rejection. Three distinct phenotypes of chronic rejection are now recognized: bronchiolitis obliterans, neutrophilic reversible allograft dysfunction, and restrictive allograft syndrome. Recent investigations have revealed that each phenotype has a unique pathology and histopathological findings, suggesting that treatment regimens should be tailored to the underlying etiology. CLAD is poorly responsive to treatment once diagnosed, and therefore the prevention of the factors that predispose a patient to develop CLAD is critically important. Small and large animal models have contributed significantly to our understanding of CLAD and more studies are needed to develop treatment regimens that are effective in humans.

Indexed as

azithromycin responsive allograft dysfunctionbronchiolitis obliteransbronchiolitis obliterans syndromechronic lung allograft dysfunctionneutrophilic reversible allograft dysfunctionrestrictive allograft syndrome

Identifiers

PMID28090432
PMCPMC5233406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.