Evidence map›Paper›PMID 28090346›Full record

ArticleObesity science & practice2016

A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference.

J de Toro-Martín, F Guénard, A Tchernof, Y Deshaies, L Pérusse, S Biron, O Lescelleur, L Biertho, S Marceau, M-C Vohl

Open access · goldAbstract read
In one paragraph

Article in Obesity science & practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

J de Toro-MartínInstitute of Nutrition and Functional Foods (INAF) Laval University Quebec Quebec Canada; School of Nutrition Laval University Quebec Quebec Canada.
F GuénardInstitute of Nutrition and Functional Foods (INAF) Laval University Quebec Quebec Canada; School of Nutrition Laval University Quebec Quebec Canada.
A TchernofSchool of Nutrition Laval University Quebec Quebec Canada; Quebec Heart and Lung Institute Research Center Quebec Quebec Canada.
Y DeshaiesQuebec Heart and Lung Institute Research Center Quebec Quebec Canada; Department of Medicine Laval University Quebec Quebec Canada.
L PérusseInstitute of Nutrition and Functional Foods (INAF) Laval University Quebec Quebec Canada; Department of Kinesiology Laval University Quebec Quebec Canada.
S BironDepartment of Surgery Laval University Quebec Quebec Canada.
O LescelleurDepartment of Surgery Laval University Quebec Quebec Canada.
L BierthoDepartment of Surgery Laval University Quebec Quebec Canada.
S MarceauDepartment of Surgery Laval University Quebec Quebec Canada.
M-C VohlInstitute of Nutrition and Functional Foods (INAF) Laval University Quebec Quebec Canada; School of Nutrition Laval University Quebec Quebec Canada.ORCID 0000-0002-7017-5848
Université Laval · CAMontreal Heart Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA novel single-nucleotide polymorphism (SNP) associated with morbid obesity was recently identified by exome sequencing. The purpose of this study was to follow up this low-frequency coding SNP located within the

methodsThe body mass index-associated SNP (rs62623713 A>G [chr1:109476817/hg19]) and two tagging SNPs within the

resultsrs9661614 and rs485660 were significantly associated with hip circumference (HC) in the obesity cohort, with heterozygotes exhibiting a significantly lower HC. These results were validated by joint analysis for rs9661614 (false discovery rate [FDR]-corrected

conclusionsThis study reveals strong evidence for a novel association between rs9661614 (T>C) and HC in women, which likely reflects a preferential association of

Indexed as

Hip circumferenceobesityreplication studySYPL2

Identifiers

PMID28090346
PMCPMC5192540
OpenAlexW2560198853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.