Evidence map›Paper›PMID 28090211›Full record

ReviewEvidence-based complementary and alternative medicine : eCAM2016

Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review.

Mallappa Kumara Swamy, Mohd Sayeed Akhtar, Uma Rani Sinniah

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04627519 (A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia), which is not on this map. Cited by 290 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
290citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04627519 naunknown statusnot on this mapstarted 2020, after this paper: background citation

A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia

TypeinterventionalSponsorUniversitas PadjadjaranRan2020 to 2021Enrolled85ConditionsCovid19ArmsRhea Health Tone®
3 · Its place in the literature

Who cites it

290 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Rosemary essential oil nanoparticles enhance antimicrobial activity and induce bacterial DNA disruption.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  7. Article
  8. Article
  9. Chemical Profiling and Antimicrobial Activity of the Leaf Essential Oil ofInternational journal of molecular sciences · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Antioxidants (Basel, Switzerland) · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

230 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mallappa Kumara SwamyDepartment of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Padmashree Institute of Management and Sciences, Kommagatta, Kengeri, Bangalore 560060, India.ORCID 0000-0002-7834-7480
Mohd Sayeed AkhtarDepartment of Botany, Gandhi Faiz-E-Aam College, Shahjahanpur, Uttar Pradesh 242001, India.ORCID 0000-0003-0251-8279
Uma Rani SinniahDepartment of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.ORCID 0000-0002-1242-9424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A wide range of medicinal and aromatic plants (MAPs) have been explored for their essential oils in the past few decades. Essential oils are complex volatile compounds, synthesized naturally in different plant parts during the process of secondary metabolism. Essential oils have great potential in the field of biomedicine as they effectively destroy several bacterial, fungal, and viral pathogens. The presence of different types of aldehydes, phenolics, terpenes, and other antimicrobial compounds means that the essential oils are effective against a diverse range of pathogens. The reactivity of essential oil depends upon the nature, composition, and orientation of its functional groups. The aim of this article is to review the antimicrobial potential of essential oils secreted from MAPs and their possible mechanisms of action against human pathogens. This comprehensive review will benefit researchers who wish to explore the potential of essential oils in the development of novel broad-spectrum key molecules against a broad range of drug-resistant pathogenic microbes.

Identifiers

PMID28090211
PMCPMC5206475

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.