Evidence map›Paper›PMID 28090091›Full record

ReviewLeukemia2017

Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.

P Valent, K Sotlar, K Blatt, K Hartmann, A Reiter, I Sadovnik, W R Sperr, P Bettelheim, C Akin, K Bauer and 8 more

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06559319 (Evaluation Of the Basophil Activation Test in Child Egg Allergy Diagnosis), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06559319 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation Of the Basophil Activation Test in Child Egg Allergy Diagnosis

TypeobservationalSponsorXia PengRan2024 to 2027Enrolled174ConditionsFood AllergyArmsblood sampling
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Review
  3. Leukocyte subtype classification with multi-model fusion.Medical & biological engineering & computing · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Monoblastic leukemia (M5a) with chronic basophilic leukemia in a cat.The Journal of veterinary medical science · 2022
    Article
  8. Acute Basophilic Leukemia Arising from Chronic Myeloid Leukemia with Isolated ThrombocytosisTurkish journal of haematology : official journal of Turkish Society of Haematology · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. The Absolute Basophil Count.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
  13. Article
  14. Article
  15. The underestimated role of basophils in PhEuropean journal of clinical investigation · 2018
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 4 countries.

P ValentDepartment of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
K SotlarInstitute of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria.
K BlattDepartment of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
K HartmannDepartment of Dermatology, University of Luebeck, Luebeck, Germany.
A ReiterDepartment of Hematology and Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
I SadovnikDepartment of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
W R SperrDepartment of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
P BettelheimDivision of Laboratory Medicine, Elisabethinen Hospital Linz, Linz, Austria.
C AkinDivision of Rheumatology, Immunology and Allergy, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
K BauerDepartment of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
T I GeorgeDepartment of Pathology, University of New Mexico, Albuquerque, NM, USA.
E HadzijusufovicDepartment of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-7409-4204
D WolfMedical Clinic III for Oncology, Haematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
J GotlibStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
F-X MahonLaboratoire d'Hématologie, CHU de Bordeaux, France.
D D MetcalfeLaboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, USA.
H-P HornyInstitute of Pathology, Ludwig-Maximilians University, Munich, Germany.
M ArockLBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France.
Ludwig Boltzmann Institute for Cardiovascular Research · ATBrigham and Women's Hospital · USCentre Hospitalier Universitaire de Bordeaux · FRÉcole Normale Supérieure Paris-Saclay · FRHeidelberg University · DEKrankenhaus der Elisabethinen · ATLudwig-Maximilians-Universität München · DENational Institutes of Health · USParacelsus Medical University · ATStanford University · USUniversity Hospital Bonn · DEUniversity of Lübeck · DEUniversity of New Mexico · US

Funding

The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell DisordersZIAAI000249 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOMAROW, HIRSH D · 2009 to 2025
$16.5M
Austrian Science Fund FWF F 4704
6 · The paper itself

Abstract

Basophils form a distinct cell lineage within the hematopoietic cell family. In various myeloid neoplasms, including chronic myeloid leukemia, basophilia is frequently seen. Acute and chronic basophilic leukemias, albeit rare, have also been described. However, no generally accepted criteria and classification of basophilic leukemias have been presented to date. To address this unmet need, a series of Working Conferences and other meetings were organized between March 2015 and March 2016. The current article provides a summary of consensus statements from these meetings, together with proposed criteria to delineate acute basophilic leukemia (ABL) from chronic basophilic leukemia (CBL) and primary forms of the disease where no preceding myeloid malignancy is detected, from the more common 'secondary' variants. Moreover, the term hyperbasophilia (HB) is proposed for cases with a persistent peripheral basophil count ⩾1000 per μl of blood. This condition, HB, is highly indicative of the presence of an underlying myeloid neoplasm. Therefore, HB is an important checkpoint in the diagnostic algorithm and requires a detailed hematologic investigation. In these patients, an underlying myeloid malignancy is often found and is then labeled with the appendix -baso, whereas primary cases of ABL or CBL are very rare. The criteria and classification proposed in this article should facilitate the diagnosis and management of patients with unexplained basophilia and basophil neoplasms in routine practice, and in clinical studies.

Indexed as

AlgorithmsBasophilsBiomarkersCell DifferentiationCell Transformation, NeoplasticCytogeneticsDiagnosis, DifferentialHumansImmunohistochemistryImmunophenotypingLeukemia, Basophilic, AcuteLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukocyte CountLeukocyte DisordersPhenotypeBiomarkers

Identifiers

PMID28090091
PMCPMC7115817
OpenAlexW2573166186

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.