Evidence map›Paper›PMID 28089917›Full record

Trial reportThe Journal of steroid biochemistry and molecular biology2017

microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma.

Shweta Dambal, Angeline A Giangreco, Andres M Acosta, Andrew Fairchild, Zachary Richards, Ryan Deaton, Dennis Wagner, Reinhold Vieth, Peter H Gann, Andre Kajdacsy-Balla and 2 more

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in The Journal of steroid biochemistry and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Serum vitamin D and PSA in elderly men in Amirkola.Caspian journal of internal medicine · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. 1,25DOncotarget · 2017
    Article
  18. Vitamin D in prostate cancer.Asian journal of andrology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Shweta DambalDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
Angeline A GiangrecoDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
Andres M AcostaDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
Andrew FairchildDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
Zachary RichardsDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
Ryan DeatonDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
Dennis WagnerDepartment of Nutritional Sciences, Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
Reinhold ViethDepartment of Nutritional Sciences, Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
Peter H GannDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States; University of Illinois Cancer Center, Chicago, IL, United States.
Andre Kajdacsy-BallaDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States; University of Illinois Cancer Center, Chicago, IL, United States.
Theodorus Van der KwastDepartment of Pathology, University Health Network, University of Toronto, ON, Canada.
Larisa NonnDepartment of Pathology, University of Illinois at Chicago, Chicago, IL, United States; University of Illinois Cancer Center, Chicago, IL, United States. Electronic address: lnonn@uic.edu.
University of Illinois Chicago · USUniversity of Toronto · CAUniversity of Illinois Urbana-Champaign · US

Funding

Significance of Vitamin D-Regulated MicroRNAs in Prostate Cancer PreventionK22CA133105 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NONN, LARISA · 2009 to 2011
$498k
Vitamin D3 alters stromal-epithelial inflammatory crosstalk in human prostateR03CA172827 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NONN, LARISA · 2013 to 2014
$157k
CIHRNCI NIH HHS K22 CA133105NCI NIH HHS R03 CA172827
6 · The paper itself

Abstract

Vitamin D deficiency increases the risk of lethal prostate adenocarcinomas (PCa) and the majority of older men are deficient. Although PCa arises from the epithelium, the surrounding stroma has hormonal regulatory control over the epithelium and contributes to carcinogenesis. Herein, we describe regulation of microRNAs (miRs) by the active hormone dihydroxyvitamin D (1,25(OH)

Indexed as

Gene Expression RegulationAgedCell DifferentiationCholecalciferolDEAD-box RNA HelicasesEpitheliumGene Expression Regulation, NeoplasticHumansImmunohistochemistryInflammationLasersMaleMicroRNAsMiddle AgedProstateProstatectomy1,25-dihydroxyvitamin DCholecalciferolDEAD-box RNA HelicasesDICER1 protein, humanMicroRNAsRibonuclease IIIVitamin DmicroRNAProstate cancerProstate stromaVitamin D

Identifiers

PMID28089917
PMCPMC5304339
OpenAlexW2574051342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.