ArticleJournal of neuroscience methods2017
Using pupil size and heart rate to infer affective states during behavioral neurophysiology and neuropsychology experiments.
Article in Journal of neuroscience methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Linking reaction time variability to physiological markers of arousal across timescales.bioRxiv : the preprint server for biology · 2026Article
- The Orbitofrontal Cortex Underlies Consolidation of Pavlovian Anticipatory Arousal Responses in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Manipulation of interoceptive signaling biases decision making in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Interoceptive Signals Bias Decision Making in Rhesus Macaques.bioRxiv : the preprint server for biology · 2024Article
- Article
- The role of the amygdala in processing social and affective touch.Current opinion in behavioral sciences · 2022Article
- Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pupil Size Prediction Techniques Based on Convolution Neural Network.Sensors (Basel, Switzerland) · 2021Article
- Autonomic arousal tracks outcome salience not valence in monkeys making social decisions.Behavioral neuroscience · 2021Article
- Piecing together the orbitofrontal puzzle.Behavioral neuroscience · 2021Article
- Dysregulation of behavioral and autonomic responses to emotional and social stimuli following bidirectional pharmacological manipulation of the basolateral amygdala in macaques.Neuropharmacology · 2020Article
- Automated video-based heart rate tracking for the anesthetized and behaving monkey.Scientific reports · 2020Article
- Multidimensional processing in the amygdala.Nature reviews. Neuroscience · 2020Review
- Article
- A Usability Study of Physiological Measurement in School Using Wearable Sensors.Sensors (Basel, Switzerland) · 2020Article
- The anterior cingulate cortex is necessary for forming prosocial preferences from vicarious reinforcement in monkeys.PLoS biology · 2020Article
- Cross-species convergence in pupillary response: understanding human anxiety via non-human primate amygdala lesion.Social cognitive and affective neuroscience · 2019Article
- Lesion Studies in Contemporary Neuroscience.Trends in cognitive sciences · 2019Review
- Differentiating between Models of Perceptual Decision Making Using Pupil Size Inferred Confidence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Distinct phase-amplitude couplings distinguish cognitive processes in human attention.NeuroImage · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNonhuman primates (NHPs) are a valuable research model because of their behavioral, physiological and neuroanatomical similarities to humans. In the absence of language, autonomic activity can provide crucial information about cognitive and affective states during single-unit recording, inactivation and lesion studies. Methods standardized for use in humans are not easily adapted to NHPs and detailed guidance has been lacking. NEW
methodWe provide guidance for monitoring heart rate and pupil size in the behavioral neurophysiology setting by addressing the methodological issues, pitfalls and solutions for NHP studies. The methods are based on comparative physiology to establish a rationale for each solution. We include examples from both electrophysiological and lesion studies.
resultsSingle-unit recording, pupil responses and heart rate changes represent a range of decreasing temporal resolution, a characteristic that impacts experimental design and analysis. We demonstrate the unexpected result that autonomic measures acquired before and after amygdala lesions are comparable despite disruption of normal autonomic function. COMPARISON WITH EXISTING
methodsSpecies and study design differences can render standard techniques used in human studies inappropriate for NHP studies. We show how to manage data from small groups typical of NHP studies, data from the short behavioral trials typical of neurophysiological studies, issues associated with longitudinal studies, and differences in anatomy and physiology.
conclusionsAutonomic measurement to infer cognitive and affective states in NHP is neither off-the-shelf nor onerous. Familiarity with the issues and solutions will broaden the use of autonomic signals in NHP single unit and lesion studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.