Evidence map›Paper›PMID 28089740›Full record

ArticleJournal of molecular and cellular cardiology2017

Early remodeling of repolarizing K

Rocco Hueneke, Adam Adenwala, Rebecca L Mellor, Jonathan G Seidman, Christine E Seidman, Jeanne M Nerbonne

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Atrial electrophysiology in hypertrophic cardiomyopathy: current insights and knowledge gaps.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Genome Editing and Pathological Cardiac Hypertrophy.Advances in experimental medicine and biology · 2023
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rocco HuenekeDepartment of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Anesthesiology, Washington University Medical School, St. Louis, MO 63110-1093, USA.
Adam AdenwalaDepartment of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA.
Rebecca L MellorDepartment of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA.
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Christine E SeidmanDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Jeanne M NerbonneDepartment of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA. Electronic address: jnerbonne@wustl.edu.
Washington University in St. Louis · USHarvard University · US

Funding

Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
ION CHANNEL REGULATION AND MODULATION IN CARDIAC MUSCLER01HL034161 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 1986 to 2015
$4.6M
REPOLARIZATION AND REMODELING IN THE MAMMALIAN HEARTR01HL066388 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2000 to 2008
$2.7M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL034161NHLBI NIH HHS R01 HL066388NHLBI NIH HHS R01 HL084553
6 · The paper itself

Abstract

Familial hypertrophic cardiomyopathy (HCM), linked to mutations in myosin, myosin-binding proteins and other sarcolemmal proteins, is associated with increased risk of life threatening ventricular arrhythmias, and a number of animal models have been developed to facilitate analysis of disease progression and mechanisms. In the experiments here, we use the αMHC

Indexed as

Action PotentialsMutationAnimalsBiopsyCardiomyopathy, Hypertrophic, FamilialDisease Models, AnimalEchocardiographyElectrocardiographyGene ExpressionGene Expression ProfilingHypertrophy, Left VentricularMaleMiceMyocardiumMyocytes, CardiacPotassium ChannelsPotassium ChannelsVentricular MyosinsECGElectrical remodelingHypertrophyKv currentsQT intervalRepolarizationTranscriptional remodeling

Identifiers

PMID28089740
PMCPMC5398411
OpenAlexW2577867575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.