Evidence map›Paper›PMID 28089709›Full record

Trial reportThe lancet. Diabetes & endocrinology2017

Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott and 6 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The lancet. Diabetes & endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04461106 (A Two-Phase Study to Investigate Novel Biomarkers of Egg Consumption and Social Marketing Effectiveness of Egg Hubs for Malawian Infants), which is not on this map. Cited by 111 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 4 pooled it
30.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04461106 nacompletednot on this mapstarted 2021, after this paper: background citation

A Two-Phase Study to Investigate Novel Biomarkers of Egg Consumption and Social Marketing Effectiveness of Egg Hubs for Malawian Infants

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2022Enrolled815ConditionsNutritional StuntingArmsSocial Marketing Campaign
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 4 syntheses or guidelines pooled it, 240 citations in OpenAlex.

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  17. Randomized trial of a clinic-based weight loss intervention in cancer survivors.Journal of cancer survivorship : research and practice · 2018
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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Isabel Garcia-PerezNutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK; Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.
Joram M PosmaBiomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.
Rachel GibsonNutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Edward S ChambersNutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Tue H HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Henrik VestergaardThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Manfred BeckmannInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Paul ElliottDepartment of Epidemiology and Biostatistics, Medical Research Council (MRC)-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; MRC-National Institute for Health Research (NIHR) National Phenome Centre, Department of Surgery and Cancer, Imperial College London, London, UK.
Jeremiah StamlerDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Jeremy K NicholsonBiomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK; MRC-National Institute for Health Research (NIHR) National Phenome Centre, Department of Surgery and Cancer, Imperial College London, London, UK.
John DraperInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
John C MathersHuman Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle, UK.
Elaine HolmesBiomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK; MRC-National Institute for Health Research (NIHR) National Phenome Centre, Department of Surgery and Cancer, Imperial College London, London, UK. Electronic address: elaine.holmes@imperial.ac.uk.
Gary FrostNutrition and Dietetic Research Group, Division of Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK. Electronic address: g.frost@imperial.ac.uk.
Imperial College London · GBNovo Nordisk Foundation · DKAberystwyth University · GBNational Institute for Health Research · GBNewcastle University · GBNorthwestern University · USUniversity of Copenhagen · DK

Funding

INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAPR01HL050490 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 1995 to 2013
$7.3M
Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTER01HL084228 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2007 to 2014
$4.2M
Department of Health PDF-2012-05-456Medical Research Council MC_PC_12025Medical Research Council MR/J010308/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1NHLBI NIH HHS R01 HL050490NHLBI NIH HHS R01 HL084228Wellcome Trust
6 · The paper itself

Abstract

backgroundAccurate monitoring of changes in dietary patterns in response to food policy implementation is challenging. Metabolic profiling allows simultaneous measurement of hundreds of metabolites in urine, the concentrations of which can be affected by food intake. We hypothesised that metabolic profiles of urine samples developed under controlled feeding conditions reflect dietary intake and can be used to model and classify dietary patterns of free-living populations.

methodsIn this randomised, controlled, crossover trial, we recruited healthy volunteers (aged 21-65 years, BMI 20-35 kg/m

findingsBetween Aug 13, 2013, and May 18, 2014, we contacted 300 people with a letter of invitation. 78 responded, of whom 26 were eligible and invited to attend a health screening. Of 20 eligible participants who were randomised, 19 completed all four 72 h study stays between Oct 2, 2013, and July 29, 2014, and consumed all the food provided. Analysis of

interpretationUrinary metabolite models developed in a highly controlled environment can classify groups of free-living people into consumers of diets associated with lower or higher non-communicable disease risk on the basis of multivariate metabolite patterns. This approach enables objective monitoring of dietary patterns in population settings and enhances the validity of dietary reporting.

fundingUK National Institute for Health Research and UK Medical Research Council.

Indexed as

DietMetabolomeAdultBiomarkersCross-Over StudiesFemaleHumansMaleMetabolomicsMiddle AgedModels, BiologicalPhenotypeYoung AdultBiomarkers

Identifiers

PMID28089709
PMCPMC5357736
OpenAlexW2574422337

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.