ArticleNeuroImage2017
Multimodal evaluation of the amygdala's functional connectivity.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The neuropathology of bipolar disorder: systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Patients With Major Depressive Disorder.Depression and anxiety · 2026Article
- Altered Functional Connectivity of Amygdala Subregions with Large-Scale Brain Networks in Schizophrenia: A Resting-State fMRI Study.Tomography (Ann Arbor, Mich.) · 2025Article
- Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders.Molecular psychiatry · 2025Article
- Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Abnormal resting-state functional connectivity in subregions of amygdala in adults and adolescents with major depressive disorder.BMC psychiatry · 2024Article
- Specialization of amygdala subregions in emotion processing.Human brain mapping · 2024Article
- Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human.Communications biology · 2024Article
- The subcortical brain regions influence the cortical areas during resting-state: an fMRI study.Frontiers in human neuroscience · 2024Article
- The subcortical default mode network and Alzheimer's disease: a systematic review and meta-analysis.Brain communications · 2024Article
- Echoes from Intrinsic Connectivity Networks in the Subcortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- Perceived danger associated with a property modulates cross category generalization.Cognitive neurodynamics · 2022Article
- Shared and distinct patterns of atypical cortical morphometry in children with autism and anxiety.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.Molecular neurodegeneration · 2022Review
- Article
- ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data.Human brain mapping · 2022Review
- Associations of Irritability With Functional Connectivity of Amygdala and Nucleus Accumbens in Adolescents and Young Adults With ADHD.Journal of attention disorders · 2022Article
- Emotion Downregulation Targets Interoceptive Brain Regions While Emotion Upregulation Targets Other Affective Brain Regions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The amygdala is one of the most extensively studied human brain regions and undisputedly plays a central role in many psychiatric disorders. However, an outstanding question is whether connectivity of amygdala subregions, specifically the centromedial (CM), laterobasal (LB) and superficial (SF) nuclei, are modulated by brain state (i.e., task vs. rest). Here, using a multimodal approach, we directly compared meta-analytic connectivity modeling (MACM) and specific co-activation likelihood estimation (SCALE)-derived estimates of CM, LB and SF task-based co-activation to the functional connectivity of these nuclei as assessed by resting state fmri (rs-fmri). Finally, using a preexisting resting state functional connectivity-derived cortical parcellation, we examined both MACM and rs-fmri amygdala subregion connectivity with 17 large-scale networks, to explicitly address how the amygdala interacts with other large-scale neural networks. Analyses revealed strong differentiation of CM, LB and SF connectivity patterns with other brain regions, both in task-dependent and task-independent contexts. All three regions, however, showed convergent connectivity with the right ventrolateral prefrontal cortex (VLPFC) that was not driven by high base rate levels of activation. Similar patterns of connectivity across rs-fmri and MACM were observed for each subregion, suggesting a similar network architecture of amygdala connectivity with the rest of the brain across tasks and resting state for each subregion, that may be modified in the context of specific task demands. These findings support animal models that posit a parallel model of amygdala functioning, but importantly, also modify this position to suggest integrative processing in the amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.