ReviewDevelopmental cognitive neuroscience2017
How do antidepressants influence the BOLD signal in the developing brain?
Review in Developmental cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
- Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity.Plants (Basel, Switzerland) · 2025Review
- Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression.Cell & bioscience · 2025Review
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks.BMC medicine · 2025Article
- The impact of depression on mothers' neural processing of their adolescents' affective behavior.Social cognitive and affective neuroscience · 2022Article
- A 7-Tesla MRI study of the periaqueductal gray: resting state and task activation under threat.Social cognitive and affective neuroscience · 2022Article
- Anti-Inflammatory Potential of Daturaolone fromPharmaceuticals (Basel, Switzerland) · 2021Article
- Multimodal Evaluation of Neurovascular Functionality in Early Parkinson's Disease.Frontiers in neurology · 2020Article
- Brain function and clinical characterization in the Boston adolescent neuroimaging of depression and anxiety study.NeuroImage. Clinical · 2020Article
- Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders.Frontiers in molecular neuroscience · 2018Review
- Development holds the key to understanding the interplay of nature versus nurture in shaping the individual.Developmental cognitive neuroscience · 2017Article
- Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression.Frontiers in cellular neuroscience · 2017Review
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a highly prevalent life-threatening disorder, with its first onset commonly occurring during adolescence. Adolescent depression is increasingly being treated with antidepressants, such as fluoxetine. The use of medication during this sensitive period of physiological and cognitive brain development produces neurobiological changes, some of which may outlast the course of treatment. In this review, we look at how antidepressant treatment in adolescence is likely to alter neurovascular coupling and brain energy use and how these changes, in turn, affect our ability to identify neuronal activity changes between participant groups. BOLD (blood oxygen level dependent) fMRI (functional magnetic resonance imaging), the method most commonly used to record brain activity in humans, is an indirect measure of neuronal activity. This means that between-group comparisons - adolescent versus adult, depressed versus healthy, medicated versus non-medicated - rely upon a stable relationship existing between neuronal activity and the BOLD response across these groups. We use data from animal studies to detail the ways in which fluoxetine may alter this relationship, and explore how these alterations may influence the interpretation of BOLD signal differences between groups that have been treated with fluoxetine and those that have not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.