Evidence map›Paper›PMID 28089560›Full record

ArticleBrain, behavior, and immunity2017

Critical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery.

Bin Zheng, Renchun Lai, Jun Li, Zhiyi Zuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bin ZhengDepartment of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA; Department of Anesthesiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
Renchun LaiDepartment of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA; Department of Anesthesiology and State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China.
Jun LiDepartment of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA.
Zhiyi ZuoDepartment of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA; Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China. Electronic address: zz3c@virginia.edu.

Funding

Volatile anesthetic effects on aging brainR01GM098308 · NIGMS · UNIVERSITY OF VIRGINIA · PI ZUO, ZHIYI · 2012 to 2015
$1.2M
Attenuation of postoperative cognitive dysfunction by amantadineR21AG047472 · NIA · UNIVERSITY OF VIRGINIA · PI ZUO, ZHIYI · 2015 to 2016
$435k
NIA NIH HHS R21 AG047472NIGMS NIH HHS R01 GM098308
6 · The paper itself

Abstract

Postoperative cognitive dysfunction worsens patient outcome after surgery. Neuroinflammation is a critical neuropathological process for it. We determined the role of P2X7 receptors, proteins that participate in inflammatory response, in the neuroinflammation induction after surgery, and whether the choice of volatile anesthetics affects its occurrence. Eight-week old C57BL/6J or P2X7 receptor knockout male mice were subjected to right carotid arterial exposure under anesthesia with 1.8% isoflurane, 2.5% sevoflurane or 10% desflurane. They were tested by Barnes maze and fear conditioning from 2weeks after the surgery. Hippocampus was harvested 6h, 24h and 7days after the surgery for immunohistochemical staining and Western blotting. Mice with surgery under anesthesia with isoflurane, sevoflurane or desflurane took longer than control mice to identify the target box 1 or 8days after the training sessions in Barnes maze. Mice anesthetized by isoflurane or sevoflurane, but not by desflurane, had less freezing behavior than control mice in fear conditioning test. Mice with surgery and anesthesia had increased ionized calcium binding adapter molecule 1 and interleukin 1β in the hippocampus but this increase was smaller in mice anesthetized with desflurane than mice anesthetized with isoflurane. Mice with surgery had increased P2X7 receptors and its downstream molecule caspase 1. Inhibition or knockout of P2X7 receptors attenuated surgery and anesthesia-induced neuroinflammation and cognitive impairment. We conclude that surgery under desflurane anesthesia may have reduced neuroinflammation and cognitive impairment compared with surgery under isoflurane anesthesia. P2X7 receptors may mediate the neuroinflammation and cognitive impairment after surgery.

Indexed as

Anesthetics, InhalationAnimalsCarotid ArteriesCognitive DysfunctionDesfluraneEncephalitisHippocampusInterleukin-1betaIsofluraneMaleMaze LearningMiceMice, KnockoutPostoperative ComplicationsReceptors, Purinergic P2X7Vascular Surgical ProceduresAnesthetics, InhalationDesfluraneInterleukin-1betaIsofluraneReceptors, Purinergic P2X7Learning and memoryNeuroinflammationP2X7 receptorsVolatile anesthetics

Identifiers

PMID28089560
PMCPMC5316360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.