ReviewTrends in cardiovascular medicine2017
Discovery of a murine model of clinical PAH: Mission impossible?
Review in Trends in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approach.Frontiers in medicine · 2024Review
- Article
- Fatty Acid Metabolism in Endothelial Cell.Genes · 2022Review
- Blood Flow Disturbances in Congenital Heart Disease: Is Neuroblastoma Suppressor of Tumorigenicity 1 a Target for Preventing Pulmonary Vascular Remodeling?American journal of respiratory cell and molecular biology · 2022Article
- Endothelial PHD2 deficiency induces nitrative stressThe European respiratory journal · 2022Article
- Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature.Journal of vascular research · 2022Article
- Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension.Pulmonary circulation · 2022Article
- Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension.International journal of molecular sciences · 2021Article
- The Challenge to Decide between Pulmonary Hypertension Due to Chronic Lung Disease and PAH with Chronic Lung Disease.Diagnostics (Basel, Switzerland) · 2021Article
- Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- CrossTalk proposal: The mouse SuHx model is a good model of pulmonary arterial hypertension.The Journal of physiology · 2019Article
- CrossTalk opposing view: The mouse SuHx model is not a good model of pulmonary arterial hypertension.The Journal of physiology · 2019Article
- Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor.American journal of respiratory and critical care medicine · 2018Article
- Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease.Biology of sex differences · 2018Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH. We will also discuss the translational potential of recent findings arising from experimental studies of murine PH models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.