Evidence map›Paper›PMID 28089266›Full record

ReviewCell calcium2017

TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces.

Indu S Ambudkar, Lorena Brito de Souza, Hwei Ling Ong

Abstract readReview
In one paragraph

Review in Cell calcium, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.

  1. Pooled it
  2. Transient receptor potential channels inChannels (Austin, Tex.) · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. The CaCell reports. Medicine · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  15. Review
  16. Article
  17. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  18. Article
  19. The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025
    Review
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Indu S AmbudkarSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: indu.ambudkar@nih.gov.
Lorena Brito de SouzaSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Hwei Ling OngSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
National Institute of Dental and Craniofacial Research · USNational Institutes of Health · US

Funding

Molecular Mechanisms Regulating Calcium Flux In Salivary GlandsZIADE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 2009 to 2025
$42.5M
Molecular Regulaton Calcium Flux In Salivary GlandsZ01DE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 1987 to 2008
$3.6M
Intramural NIH HHS Z01 DE000438
6 · The paper itself

Abstract

Store-operated calcium entry (SOCE) is a ubiquitous Ca

Indexed as

AnimalsCalciumCell MembraneHumansIon TransportORAI1 ProteinStromal Interaction Molecule 1TRPC Cation ChannelsCalciumORAI1 ProteinStromal Interaction Molecule 1TRPC Cation ChannelsCaveolinER-PM junctionsLipid raftsOrai1SOCESTIM1TRPC

Identifiers

PMID28089266
PMCPMC5466534
OpenAlexW2562874465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.