Evidence map›Paper›PMID 28089218›Full record

ArticleTrends in immunology2017

NKG2D Signaling: The Immune Subversive Side of HDAC3.

Alicia R Folgueras, Segundo Gonzalez, Alejandro López-Soto

Open access · greenAbstract readComment
PubMed Publisher
In one paragraph

Article in Trends in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alicia R FolguerasDepartamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
Segundo GonzalezDepartamento de Biología Funcional, Inmunología, Facultad de Medicina, IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain.
Alejandro López-SotoDepartamento de Biología Funcional, Inmunología, Facultad de Medicina, IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain; Hospital Universitario Central de Asturias (HUCA), Fundación para la Investigación e Innovación Biosanitaria en el Principado de Asturias (FINBA), 33006 Oviedo, Spain. Electronic address: lopezsalejandro@uniovi.es.
Universidad de Oviedo · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through inhibition of casein kinase 2 (CK2), an activator of the repressor histone deacetylase HDAC3.

Indexed as

AnimalsCasein Kinase IICytotoxicity, ImmunologicEpigenesis, GeneticHEK293 CellsHerpesviridae InfectionsHistone Deacetylase 3Histone DeacetylasesHumansImmunity, InnateKiller Cells, NaturalMembrane ProteinsMiceMuromegalovirusNK Cell Lectin-Like Receptor Subfamily KSignal TransductionCasein Kinase IIHistone Deacetylase 3Histone DeacetylasesMembrane ProteinsNK Cell Lectin-Like Receptor Subfamily KRaet1e protein, mouseSp3 Transcription Factor

Identifiers

PMID28089218
OpenAlexW2577343429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.