ReviewSeminars in hematology2017
The epigenetic basis of hematopoietic stem cell aging.
Review in Seminars in hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Review
- AbioRxiv : the preprint server for biology · 2026Article
- Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities.Aging and disease · 2025Review
- Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs.Frontiers in aging · 2025Article
- Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders.Current hematologic malignancy reports · 2024Review
- TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.Nature aging · 2023Article
- A novel Boolean network inference strategy to model early hematopoiesis aging.Computational and structural biotechnology journal · 2023Article
- Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023Article
- Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice.Nature aging · 2022Article
- Single Cell Transcriptomics to Understand HSC Heterogeneity and Its Evolution upon Aging.Cells · 2022Review
- Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.Nature cell biology · 2021Article
- Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson's disease.BMC genomics · 2021Article
- Article
- Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6.Nature reviews. Cardiology · 2021Review
- Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.Journal of hematology & oncology · 2020Review
- Understanding intrinsic hematopoietic stem cell aging.Haematologica · 2020Review
- The eroding chromatin landscape of aging stem cells.Translational medicine of aging · 2020Article
- DNA methylation-based prognostic biomarkers of acute myeloid leukemia patients.Annals of translational medicine · 2019Article
- Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies.Cells · 2019Review
- Causes and Mechanisms of Hematopoietic Stem Cell Aging.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Highly proliferative tissues such as the gut, skin, and bone marrow lose millions of cells each day to normal attrition and challenge from different biological adversities. To achieve a lifespan beyond the longevity of individual cell types, tissue-specific stem cells sustain these tissues throughout the life of a human. For example, the lifespan of erythrocytes is about 100 days and adults make about two million new erythrocytes every second. A small pool of hematopoietic stem cells (HSCs) in the bone marrow is responsible for the lifetime maintenance of these populations. However, there are changes that occur within the HSC pool during aging. Biologically, these changes manifest as blunted immune responses, decreased bone marrow cellularity, and increased risk of myeloid diseases. Understanding the molecular mechanisms underlying dysfunction of aging HSCs is an important focus of biomedical research. With advances in modern health care, the average age of the general population is ever increasing. If molecular or pharmacological interventions could be discovered that rejuvenate aging HSCs, it could reduce the burden of age related immune system compromise as well as open up new opportunities for treatment of hematological disorders with regenerative therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.