ArticleBiosensors & bioelectronics2017
Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays.
Article in Biosensors & bioelectronics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692830 (Towards a Wearable Alcohol Biosensor), which is not on this map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms
Who cites it
74 citing papers in PubMed, 267 citations in OpenAlex.
- Bioelectronic Considerations in Biomedical Microneedles.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Highly cited original research in microneedle science from 2015 to 2025 a bibliometric and altmetric analysis.Discover nano · 2026Review
- Wearable technologies in clinical trials for drug development: trends and emerging opportunities.Nature reviews. Drug discovery · 2026Review
- Objective Assessment in Clinical Psychological Science: Progress in Wearable Alcohol Biosensors.Annual review of clinical psychology · 2026Review
- Machine learning-enabled implantable plant biomarker sensor for early detection and classification of acid and salt stress.Nature communications · 2026Article
- Development of a Flexible Microneedle Array Electrode with a High Signal-to-Noise Ratio for Surface Bioelectrical Signal Recording.Biosensors · 2026Article
- Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential.Advanced healthcare materials · 2026Review
- Recent progress of NIR light-controlled microneedles and therapeutic applications: A review study.Journal of materials science. Materials in medicine · 2025Review
- Microneedle-nanoparticle hybrid platforms for metabolic syndrome: advances in point-of-care diagnostics and transdermal therapeutics.Discover nano · 2025Review
- From mechanism to applications: Advanced microneedles for clinical medicine.Bioactive materials · 2025Review
- Microneedles at the Forefront of Next Generation Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Recent advances and perspectives of MicroNeedles for biomedical applications.Biophysical reviews · 2025Review
- Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection.Biosensors · 2025Review
- Microneedles in biomedicine: Innovations, challenges, and future prospects.Biomaterials translational · 2025Review
- Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Self-Extracting Dextran-Based Hydrogel Microneedle Arrays with an Interpenetrating Bioelectroenzymatic Sensor for Transdermal Monitoring with Matrix Protection.Advanced healthcare materials · 2025Article
- Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems.Advanced healthcare materials · 2024Review
- Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.Bioengineered · 2024Review
- Advances in microneedles for transdermal diagnostics and sensing applications.Mikrochimica acta · 2024Review
- Microneedle Sensors for Point-of-Care Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire microtransducer, followed by the immobilization of alcohol oxidase (AOx) in an intermediate chitosan layer, along with an outer Nafion layer. The resulting microneedle-based enzyme electrode displays an interference-free ethanol detection in artificial interstitial fluid without compromising its sensitivity, stability and response time. The skin penetration ability and the efficaciousness of the biosensor performance towards subcutaneous alcohol monitoring was substantiated by the ex vivo mice skin model analysis. Our results reveal that the new microneedle sensor holds considerable promise for continuous non-invasive alcohol monitoring in real-life situations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.