Evidence map›Paper›PMID 28088741›Full record

ArticleAddictive behaviors2017

Prevalence and correlates of fentanyl-contaminated heroin exposure among young adults who use prescription opioids non-medically.

Alexandria Macmadu, Jennifer J Carroll, Scott E Hadland, Traci C Green, Brandon D L Marshall

Abstract read
In one paragraph

Article in Addictive behaviors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  10. Acute opioid overdose in pediatric patients.Journal of the American College of Emergency Physicians open · 2024
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alexandria MacmaduThe Center for Prisoner Health and Human Rights, The Miriam Hospital, 8 Third Street, Providence, RI 02906, USA; Department of Health Services, Policy and Practice, Brown University School of Public Health, 121 South Main Street, Box G-S-121-7, Providence, RI 02912, USA.
Jennifer J CarrollThe Division of Infectious Diseases, The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA; Department of Medicine, The Warren Alpert School of Medicine of Brown University, 222 Richmond Street, Providence, RI 02903, USA.
Scott E HadlandDepartment of Pediatrics, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA.
Traci C GreenDepartment of Emergency Medicine, Boston University School of Medicine, 771 Albany Street, Boston, MA 02118, USA; Department of Emergency Medicine, The Warren Alpert School of Medicine of Brown University, 222 Richmond Street, Providence, RI 02903, USA; Injury Prevention Center, Boston Medical Center, 771 Albany Street, Dowling South 1, Boston, MA 02118, USA.
Brandon D L MarshallThe Center for Prisoner Health and Human Rights, The Miriam Hospital, 8 Third Street, Providence, RI 02906, USA; Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2, Providence, RI 02912, USA. Electronic address: brandon_marshall@brown.edu.
Boston University · USBrown University · USProvidence College · US

Funding

HIV and Other Infectious Consequences of Substance UseT32DA013911 · NIDA · MIRIAM HOSPITAL · PI TRACI C GREEN, JOSIAH D RICH · 2001 to 2026
$9.6M
Research Training in Prevention and Care of Chronic Illness in ChildhoodT32HD075727 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI FINKELSTEIN, JONATHAN A · 2013 to 2017
$1.5M
Advancing Patient Safety Implementation through Pharmacy-Based Opioid Medication Use ResearchR18HS024021 · AHRQ · BOSTON MEDICAL CENTER · PI GREEN, TRACI C · 2015 to 2015
$1.3M
Local health impacts of Prescription Monitoring Program useU01CE002165 · CE · INFLEXXION, INC. · PI PAVEK, MILA · 2012 to 2013
$374k
Unintentional Prescription Opioid Poisoning Deaths in Connecticut and Rhode IslanR21CE001846 · CE · RHODE ISLAND HOSPITAL · PI GREEN, TRACI C · 2010 to 2011
$350k
Exploring transitions to injecting among young adult non-medical opioid usersR03DA037770 · NIDA · BROWN UNIVERSITY · PI MARSHALL, BRANDON DAVID LEWIS · 2014 to 2015
$335k
AHRQ HHS R18 HS024021NCIPC CDC HHS R21 CE001846NCIPC CDC HHS U01 CE002165NICHD NIH HHS T32 HD075727NIDA NIH HHS R03 DA037770NIDA NIH HHS T32 DA013911
6 · The paper itself

Abstract

backgroundThe rate of overdose deaths caused by fentanyl-contaminated heroin (FCH) use is increasing rapidly in the United States. We examined risk factors for exposure to FCH and experiences with FCH use among young adult non-medical prescription opioids (NMPO) users.

methodsWe analyzed data from the Rhode Island Young Adult Prescription Drug Study (RAPiDS), which enrolled young adults aged 18 to 29 reporting prior 30day NMPO use between January 2015 and February 2016. Participants completed questionnaires ascertaining drug use patterns and risk behaviors, including FCH exposure. Logistic regression was used to assess factors associated with known or suspected FCH exposure.

resultsOf 199 participants, the median age was 25 (IQR: 22, 27), 130 (65.3%) were male, and 122 (61.3%) were of White, non-Hispanic race/ethnicity. In total, 22 (11%) reported known or suspected FCH exposure in the prior six months. Several drug use patterns and risk behaviors were associated with FCH exposure, including: regular heroin and cocaine use; diverted pharmaceutical fentanyl use in the prior six months; NMPO use to avoid withdrawal symptoms; longer duration of NMPO use; regular injection drug use; and prior overdose (all p<0.001). Among participants who reported FCH exposure, 59% were unaware that their heroin was contaminated with fentanyl prior to last use, 59% reported that FCH provides a better high, and all recognized that fentanyl increases overdose risk.

conclusionsExposure to fentanyl-contaminated heroin is an emerging trend among young adult NMPO users in Rhode Island. Overdose prevention programs addressing FCH use are urgently needed.

Indexed as

Analgesics, OpioidFentanylHeroinAdultFemaleHealth Knowledge, Attitudes, PracticeHumansMaleOpioid-Related DisordersPilot ProjectsPrescription Drug MisusePrevalenceRhode IslandRisk FactorsRisk-TakingSurveys and QuestionnairesAnalgesics, OpioidFentanylHeroinFentanylHeroinNon-medical prescription opioid useYoung adults

Identifiers

PMID28088741
PMCPMC5291510
OpenAlexW2568909074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.