Evidence map›Paper›PMID 28088614›Full record

ArticleCytokine2017

CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE.

Michelle R Simpson-Abelson, Gerard Hernandez-Mir, Erin E Childs, J Agustin Cruz, Amanda C Poholek, Ansuman Chattopadhyay, Sarah L Gaffen, Mandy J McGeachy

Open access · greenAbstract read
In one paragraph

Article in Cytokine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  7. Transcriptome Study of 2 Black Cohorts RevealsJournal of the American Heart Association · 2024
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  15. A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michelle R Simpson-AbelsonDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Gerard Hernandez-MirDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Erin E ChildsDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
J Agustin CruzDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Amanda C PoholekDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, Children's Hospital of UPMC, Pittsburgh, PA, USA.
Ansuman ChattopadhyayMolecular Biology Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, PA, USA.
Sarah L GaffenDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: Sarah.Gaffen@pitt.edu.
Mandy J McGeachyDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: Mmcgeach@pitt.edu.
University of Pittsburgh · US

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
IL-23/STAT3-Driven Oral Immune Responses to Candida albicansR01DE023815 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9M
Negative Control of IL-17R Signaling: Implications for Fungal ImmunityR01AI107825 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9M
Regulation of Th17 Functions in Autoimmune CNS InflammationR01AI110822 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J · 2015 to 2019
$1.7M
Regulation of Th17 Functions in Autoimmune CNS InflammationR56AI110822 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J · 2014 to 2014
$369k
IL-17-Induced Regulation of C/EBPbetaF32AI098243 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMPSON-ABELSON, MICHELLE ROSAN · 2012 to 2012
$52k
NIAID NIH HHS F32 AI098243NIAID NIH HHS R01 AI107825NIAID NIH HHS R01 AI110822NIAID NIH HHS R56 AI110822NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R01 DE023815NIDCR NIH HHS R37 DE022550
6 · The paper itself

Abstract

The CCAAT/Enhancer Binding Protein β (C/EBPβ) transcription factor is activated by multiple inflammatory stimuli, including IL-17 and LPS, and C/EBPβ itself regulates numerous genes involved in inflammation. However, the role of C/EBPβ in driving autoimmunity is not well understood. Here, we demonstrate that Cebpb

Indexed as

AnimalsCCAAT-Enhancer-Binding Protein-betaCytokinesDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalGene Expression RegulationMiceMice, KnockoutReceptors, InterleukinTh17 CellsCCAAT-Enhancer-Binding Protein-betaCebpb protein, mouseCytokinesinterleukin-23 receptor, mouseReceptors, InterleukinC/EBPβEAEIL-17IL-23RTh17Transcription factor

Identifiers

PMID28088614
PMCPMC5337143
OpenAlexW2576950711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.