Evidence map›Paper›PMID 28088597›Full record

Trial reportJournal of the American College of Surgeons2017

Phase II Randomized Trial of Negative-Pressure Wound Therapy to Decrease Surgical Site Infection in Patients Undergoing Laparotomy for Gastrointestinal, Pancreatic, and Peritoneal Surface Malignancies.

Perry Shen, Aaron U Blackham, Stacey Lewis, Clancy J Clark, Russell Howerton, Harveshp D Mogal, Rebecca M Dodson, Gregory B Russell, Edward A Levine

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American College of Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05050786 (Prophylactic Negative-Pressure Wound Treatment), which is not on this map. Cited by 43 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 13 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05050786 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Prophylactic Negative-Pressure Wound Treatment (NPWT) for Patients Undergoing Elective Open Incisional Hernia Repair: the PROPRESS Trial

TypeinterventionalSponsorKristian Kiim JensenRan2022 to 2023Enrolled110ConditionsIncisional Hernia, Surgical Wound Infection, Surgical Site Infection, Quality of LifeArmsNegative Wound Pressure Therapy (Prevena(TM)), Standard Wound Dressing
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 13 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Perry ShenDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC. Electronic address: pshen@wakehealth.edu.
Aaron U BlackhamDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Stacey LewisWake Forest Baptist Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, NC.
Clancy J ClarkDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Russell HowertonDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Harveshp D MogalDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Rebecca M DodsonDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Gregory B RussellDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Edward A LevineDepartment of General Surgery, Section of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Wake Forest University · USAmerican College of Surgeons · USAtrium Health Wake Forest Baptist · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
NCI NIH HHS P30 CA012197
6 · The paper itself

Abstract

backgroundSurgical site infections (SSIs) remain a major source of morbidity and cost after resection of intra-abdominal malignancies. Negative-pressure wound therapy (NPWT) has been reported to significantly reduce SSIs when applied to the closed laparotomy incision. This article reports the results of a randomized clinical trial examining the effect of NPWT on SSI rates in surgical oncology patients with increased risk for infectious complications. STUDY

designFrom 2012 to 2016, two hundred and sixty-five patients who underwent open resection of intra-abdominal neoplasms were stratified into 3 groups: gastrointestinal (n = 57), pancreas (n = 73), or peritoneal surface (n = 135) malignancy. They were randomized to receive NPWT or standard surgical dressing (SSD) applied to the incision from postoperative days 1 through 4. Primary outcomes of combined incisional (superficial and deep) SSI rates were assessed up to 30 days after surgery.

resultsThere were no significant differences in superficial SSIs (12.8% vs 12.9%; p > 0.99) or deep SSI (3.0% vs 3.0%; p > 0.99) rates between the SSD and NPWT groups, respectively. When stratified by type of surgery, there were still no differences in combined incisional SSI rates for gastrointestinal (25% vs 24%; p > 0.99), pancreas (22% vs 22%; p > 0.99), and peritoneal surface malignancy (9% vs 9%; p > 0.99) patients. When performing univariate and multivariate logistic regression analysis of demographic and operative factors for the development of combined incisional SSI, the only independent predictors were preoperative albumin (p = 0.0031) and type of operation (p = 0.018).

conclusionsUse of NPWT did not significantly reduce incisional SSI rates in patients having open resection of gastrointestinal, pancreatic, or peritoneal surface malignancies. Based on these results, at this time NPWT cannot be recommended as a therapeutic intervention to decrease infectious complications in these patient populations.

Indexed as

LaparotomyNegative-Pressure Wound TherapyAdolescentAdultAgedAged, 80 and overDigestive System NeoplasmsFemaleFollow-Up StudiesHumansIncidenceLogistic ModelsMaleMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID28088597
PMCPMC5498990
OpenAlexW2575619591

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.