Evidence map›Paper›PMID 28088071›Full record

ArticleJournal of the mechanical behavior of biomedical materials2017

Discrete quasi-linear viscoelastic damping analysis of connective tissues, and the biomechanics of stretching.

Behzad Babaei, Aaron J Velasquez-Mao, Stavros Thomopoulos, Elliot L Elson, Steven D Abramowitch, Guy M Genin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. The fibrous character of pericellular matrix mediates cell mechanotransduction.Journal of the mechanics and physics of solids · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix.Journal of the mechanical behavior of biomedical materials · 2018
    Article
  9. Article
  10. The fibrous cellular microenvironment, and how cells make sense of a tangled web.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Behzad BabaeiDepartment of Mechanical Engineering & Materials Science, and NSF Center for Engineering MechanoBiology, Washington University in St. Louis, St. Louis, MO, USA.
Aaron J Velasquez-MaoDepartment of Bioengineering, Rice University,Houston, TX, USA.
Stavros ThomopoulosOrthopaedic Surgery, School of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Elliot L ElsonDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Steven D AbramowitchMusculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh Pittsburgh, USA.
Guy M GeninDepartment of Mechanical Engineering & Materials Science, and NSF Center for Engineering MechanoBiology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: genin@wustl.edu.

Funding

IN VIVO MEASUREMENT OF BRAIN BIOMECHANICSR01NS055951 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2007 to 2017
$3.9M
Cross-scale interactions between mineral and collagen for tendon-bone attachmentU01EB016422 · NIBIB · WASHINGTON UNIVERSITY · PI GENIN, GUY M, THOMOPOULOS, STAVROS · 2013 to 2017
$2.4M
THE EFFECTS OF MYOFIBROBLASTS ON ELECTROMECHANICAL FUNCTION OF MODEL HEART TISSUER01HL109505 · NHLBI · WASHINGTON UNIVERSITY · PI ELSON, ELLIOT L., GENIN, GUY M · 2012 to 2015
$2.0M
NHLBI NIH HHS R01 HL109505NIBIB NIH HHS U01 EB016422NINDS NIH HHS R01 NS055951
6 · The paper itself

Abstract

The time- and frequency-dependent properties of connective tissue define their physiological function, but are notoriously difficult to characterize. Well-established tools such as linear viscoelasticity and the Fung quasi-linear viscoelastic (QLV) model impose forms on responses that can mask true tissue behavior. Here, we applied a more general discrete quasi-linear viscoelastic (DQLV) model to identify the static and dynamic time- and frequency-dependent behavior of rabbit medial collateral ligaments. Unlike the Fung QLV approach, the DQLV approach revealed that energy dissipation is elevated at a loading period of ∼10s. The fitting algorithm was applied to the entire loading history on each specimen, enabling accurate estimation of the material's viscoelastic relaxation spectrum from data gathered from transient rather than only steady states. The application of the DQLV method to cyclically loading regimens has broad applicability for the characterization of biological tissues, and the results suggest a mechanistic basis for the stretching regimens most favored by athletic trainers.

Indexed as

Models, BiologicalAlgorithmsAnimalsBiomechanical PhenomenaConnective TissueElasticityLinear ModelsMuscle Stretching ExercisesRabbitsStress, MechanicalViscosityDiscrete quasi-linear viscoelastic modelLigamentQuasi-linear viscoelasticityRelaxation spectrumStorage and loss modulusStress relaxation

Identifiers

PMID28088071
PMCPMC5359087

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.