Evidence map›Paper›PMID 28087841›Full record

ArticleGenome research2017

Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immune cell types.

Santiago J Carmona, Sarah A Teichmann, Lauren Ferreira, Iain C Macaulay, Michael J T Stubbington, Ana Cvejic, David Gfeller

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 147 citations in OpenAlex.

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  13. Direct male development in chromosomally ZZ zebrafish.Frontiers in cell and developmental biology · 2024
    Article
  14. Zebrafish Thrombocyte Transcriptome Analysis and Functional Genomics.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. The Immune Response to the Myxozoan ParasiteInternational journal of molecular sciences · 2023
    Review
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Santiago J CarmonaLudwig Center for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland.ORCID 0000-0002-2495-0671
Sarah A TeichmannEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-6294-6366
Lauren FerreiraWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom.
Iain C MacaulaySanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom.
Michael J T StubbingtonEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Ana CvejicWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom.ORCID 0000-0003-3204-9311
David GfellerLudwig Center for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland.ORCID 0000-0002-3952-0930
European Bioinformatics Institute · GBSIB Swiss Institute of Bioinformatics · CHWellcome/MRC Cambridge Stem Cell Institute · GBWellcome Sanger Institute · GB

Funding

Cancer Research UK 14953Cancer Research UK C45041/A14953European Research Council 677501Medical Research Council MC_PC_12009Wellcome Trust
6 · The paper itself

Abstract

The immune system of vertebrate species consists of many different cell types that have distinct functional roles and are subject to different evolutionary pressures. Here, we first analyzed conservation of genes specific for all major immune cell types in human and mouse. Our results revealed higher gene turnover and faster evolution of

Indexed as

Evolution, MolecularTranscriptomeAnimalsCells, CulturedConserved SequenceHumansKiller Cells, NaturalMiceReceptors, IgGSingle-Cell AnalysisZebrafishZebrafish ProteinsReceptors, IgGZebrafish Proteins

Identifiers

PMID28087841
PMCPMC5340972
OpenAlexW2572647583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.