Evidence map›Paper›PMID 28087819›Full record

ArticlePhysiological reports2017

Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts.

Gregory S Hoeker, Mark A Skarsfeldt, Thomas Jespersen, Steven Poelzing

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Gregory S HoekerBiomedical Engineering and Mechanics, Center for Heart and Regenerative Medicine, Virginia Tech Virginia Tech Carilion Research Institute, Roanoke, Virginia.
Mark A SkarsfeldtDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thomas JespersenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Steven PoelzingBiomedical Engineering and Mechanics, Center for Heart and Regenerative Medicine, Virginia Tech Virginia Tech Carilion Research Institute, Roanoke, Virginia poelzing@vtc.vt.edu.
University of Copenhagen · DKCarilion Clinic · USCarilion Roanoke Memorial Hospital · US

Funding

Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
NHLBI NIH HHS R01 HL102298
6 · The paper itself

Abstract

The pentamidine analog PA-6 was developed as a specific inward rectifier potassium current (I

Indexed as

Action PotentialsAnimalsAnthraquinonesBarium CompoundsChloridesElectrophysiological PhenomenaGuinea PigsHeartHeart Conduction SystemHeart VentriclesHypokalemiaMalePentamidinePotassiumPotassium Channel BlockersPotassium Channels1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaineAnthraquinonesbarium chlorideBarium CompoundsChloridesPentamidinePotassiumPotassium Channel BlockersPotassium Channelsptilometric acid 6-O-sulfatePyridinium CompoundsAction potentialconduction velocityinward rectifier currentpentamidinepotassiumrepolarization

Identifiers

PMID28087819
PMCPMC5256165
OpenAlexW2579869531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.