Evidence map›Paper›PMID 28087785›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences.

Brian F Thomas, Timothy W Lefever, Ricardo A Cortes, Megan Grabenauer, Alexander L Kovach, Anderson O Cox, Purvi R Patel, Gerald T Pollard, Julie A Marusich, Richard C Kevin and 2 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. ΔDrug and alcohol dependence reports · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. The Spicy Story of Cannabimimetic Indoles.Molecules (Basel, Switzerland) · 2021
    Review
  9. ΔDrug and alcohol dependence · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Synthetic Cannabinoid Hydroxypentyl Metabolites Retain Efficacy at Human Cannabinoid Receptors.The Journal of pharmacology and experimental therapeutics · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Brian F ThomasRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.) bft@rti.org jwiley@rti.org.
Timothy W LefeverRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Ricardo A CortesRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Megan GrabenauerRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Alexander L KovachRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Anderson O CoxRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Purvi R PatelRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Gerald T PollardRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Julie A MarusichRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Richard C KevinRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Thomas F GamageRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.).
Jenny L WileyRTI International, Research Triangle Park, North Carolina (B.F.T., T.W.L., R.A.C., M.G., A.L.K., A.O.C, P.R.P, J.A.M, T.F.G, J.L.W.); Howard Associates, LLC, Research Triangle Park, North Carolina (G.T.P.); and School of Psychology, The University of Sydney, NSW, Australia (R.C.K.) bft@rti.org jwiley@rti.org.
University of Sydney · AURTI International · US

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA040460
6 · The paper itself

Abstract

Synthetic cannabinoids are manufactured clandestinely with little quality control and are distributed as herbal "spice" for smoking or as bulk compound for mixing with a solvent and inhalation via electronic vaporizers. Intoxication with synthetic cannabinoids has been associated with seizure, excited delirium, coma, kidney damage, and other disorders. The chemical alterations produced by heating these structurally novel compounds for consumption are largely unknown. Here, we show that heating synthetic cannabinoids containing tetramethylcyclopropyl-ring substituents produced thermal degradants with pharmacological activity that varied considerably from their parent compounds. Moreover, these degradants were formed under conditions simulating smoking. Some products of combustion retained high affinity at the cannabinoid 1 (CB

Indexed as

AnimalsCannabinoidsDesigner DrugsDose-Response Relationship, DrugDronabinolHEK293 CellsHot TemperatureHumansIndolesMaleMiceMice, Inbred C57BLMice, Inbred ICRNaphthalenesProtein BindingReceptor, Cannabinoid, CB11-pentyl-3-(1-naphthoyl)indoleCannabinoidsCNR2 protein, humanDesigner DrugsDronabinolIndolesNaphthalenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2

Identifiers

PMID28087785
PMCPMC5363769
OpenAlexW2577536653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.