ArticleMolecular biology and evolution2017
Genomics of Parallel Experimental Evolution in Drosophila.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Aging in Spaceflight, Oxidative Stress, and Microbiome Dysbiosis: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Beyond fixation: persistent genetic variation under intense selection.Molecular biology and evolution · 2026Article
- Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026Article
- Parallel adaptive responses to postponed reproduction increase lifespan and immune defense.bioRxiv : the preprint server for biology · 2026Article
- Historical contingency limits adaptive diversification in a spatially structured environment.Evolution letters · 2026Article
- The Field and Function of the Negro College in STEM 2025.Integrative and comparative biology · 2025Article
- Ecological stoichiometry and life history theory, not the identity of genomic variants, predict rapid adaptation.bioRxiv : the preprint server for biology · 2025Article
- Genome-wide analyses reveal intricate genetic mechanisms underlying egg production efficiency in chickens.Journal of animal science and biotechnology · 2025Article
- Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations ofEvolution letters · 2025Article
- Age-Dependent Immune Defense AgainstJournal of fungi (Basel, Switzerland) · 2025Article
- Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation.Molecular ecology · 2025Article
- Selection for Early Reproduction Leads to Accelerated Aging and Extensive Metabolic Remodeling in Drosophila melanogaster.Genome biology and evolution · 2025Article
- Genomewide architecture of adaptation in experimentally evolvedJournal of genetics · 2024Article
- 3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex.Aging cell · 2023Article
- A genomic analysis of the University of Nebraska Replicated Recurrent Selection program.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Embracing Complexity: Yeast Evolution Experiments Featuring Standing Genetic Variation.Journal of molecular evolution · 2023Review
- Revisiting the Design of the Long-Term Evolution Experiment with Escherichia coli.Journal of molecular evolution · 2023Review
- How predictable is adaptation from standing genetic variation? Experimental evolution inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Genome-wide selection signatures reveal widespread synergistic effects of two different stressors inProceedings. Biological sciences · 2022Article
- Population bottleneck has only marginal effect on fitness evolution and its repeatability in dioecious Caenorhabditis elegans.Evolution; international journal of organic evolution · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What are the genomic foundations of adaptation in sexual populations? We address this question using fitness-character and whole-genome sequence data from 30 Drosophila laboratory populations. These 30 populations are part of a nearly 40-year laboratory radiation featuring 3 selection regimes, each shared by 10 populations for up to 837 generations, with moderately large effective population sizes. Each of 3 sets of the 10 populations that shared a selection regime consists of 5 populations that have long been maintained under that selection regime, paired with 5 populations that had only recently been subjected to that selection regime. We find a high degree of evolutionary parallelism in fitness phenotypes when most-recent selection regimes are shared, as in previous studies from our laboratory. We also find genomic parallelism with respect to the frequencies of single-nucleotide polymorphisms, transposable elements, insertions, and structural variants, which was expected. Entirely unexpected was a high degree of parallelism for linkage disequilibrium. The evolutionary genetic changes among these sexual populations are rapid and genomically extensive. This pattern may be due to segregating functional genetic variation that is abundantly maintained genome-wide by selection, variation that responds immediately to changes of selection regime.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.