Evidence map›Paper›PMID 28087701›Full record

ArticleThe Journal of biological chemistry2017

The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon.

Chong Jiang, Hiroshi Kawabe, Daniela Rotin

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Dietary NaCellular and molecular life sciences : CMLS · 2023
    Article
  2. Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis.Translational research : the journal of laboratory and clinical medicine · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Elevated intracellular NaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Congenital Deletion ofInternational journal of molecular sciences · 2021
    Article
  14. Article
  15. Aldosterone up-regulates basolateral NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  16. High glucose-induced effects on NaAmerican journal of physiology. Cell physiology · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Chong JiangHospital for Sick Children and University of Toronto, Toronto, Ontario M5G 0A4, Canada.
Hiroshi KawabeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3D, 37075 Goettingen, Germany.
Daniela RotinHospital for Sick Children and University of Toronto, Toronto, Ontario M5G 0A4, Canada. Electronic address: drotin@sickkids.ca.
Hospital for Sick Children · CAMax Planck Institute of Experimental Medicine · DESickKids Foundation · CA

Funding

CIHR MOP-130422
6 · The paper itself

Abstract

The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds to and regulates stability of the epithelial Na

Indexed as

AnimalsChloridesColonEndosomal Sorting Complexes Required for TransportEpithelial Sodium ChannelsHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutNedd4 Ubiquitin Protein LigasesPotassiumSaltsSignal TransductionSodiumSolute Carrier Family 12, Member 2ChloridesEndosomal Sorting Complexes Required for TransportEpithelial Sodium ChannelsNedd4L protein, humanNedd4l protein, mouseNedd4 protein, humanNedd4 Ubiquitin Protein LigasesPotassiumSaltsSlc12a2 protein, mouseSodiumSolute Carrier Family 12, Member 2Ubiquitin-Protein Ligasescell biologyE3 ubiquitin ligaseepithelial sodium channel (ENaC)gene knockoutintestinemembrane transportubiquitin

Identifiers

PMID28087701
PMCPMC5336150
OpenAlexW2575004706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.