ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Incorporating Persistent Pain in Phenotypic Frailty Measurement and Prediction of Adverse Health Outcomes.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Association between frailty and chronic pain among older adults: a systematic review and meta-analysis.European geriatric medicine · 2020Pooled it
- Performance-Based and Self-Reported Frailty in Older Adults with or Without Fibromyalgia.European journal of investigation in health, psychology and education · 2026Article
- Pain characteristics and incident frailty in community-dwelling older adults: dose-response relationships and sex differences in a longitudinal study on aging in Taiwan.Frontiers in public health · 2026Article
- From age to frailty: redefining chronic pain characterization.Aging clinical and experimental research · 2025Article
- Is the experience of chronic pain different in frail older adults? A cross-sectional exploratory study.Arquivos de neuro-psiquiatria · 2025Article
- Ultrasound-guided training on Fascia Iliaca Compartment Block and Pericapsular Nerve Group Block for 5International journal of emergency medicine · 2025Article
- Temporal association between chronic pain and frailty occurrence, and the modifiable role of a healthy lifestyle in Chinese middle-aged and older population: a community based, prospective cohort study.Aging clinical and experimental research · 2025Article
- An Analysis of Factors Associated with Chronic Musculoskeletal Pain, Pain Management Preferences, Coping Strategies, and Health-Related Quality of Life Among Older People: A Cross-Cultural Study.Journal of pain research · 2025Article
- Patients' strategies for numeric pain assessment: a qualitative interview study of individuals with hypermobile Ehlers-Danlos Syndrome.Disability and rehabilitation · 2024Article
- The vicious cycle of frailty and pain: a two-sided causal relationship revealed.Frontiers in medicine · 2024Article
- Association between persistent musculoskeletal pain and incident sarcopenia in China: the mediating effect of depressive symptoms.Frontiers in public health · 2024Article
- Managing Musculoskeletal Pain in Older Adults Through a Digital Care Solution: Secondary Analysis of a Prospective Clinical Study.JMIR rehabilitation and assistive technologies · 2023Article
- The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort.BMC geriatrics · 2023Article
- The role of frailty in the association between depression and fall risk among older adults.Aging & mental health · 2022Article
- Frailty Risks of Prescription Analgesics and Sedatives across Frailty Models: the Health and Retirement Study.Drugs & aging · 2022Article
- Pain and the Alzheimer's Disease and Related Dementia Spectrum in Community-Dwelling Older Americans: A Nationally Representative Study.Journal of pain and symptom management · 2022Article
- Article
- Suffering in silence: a qualitative study of older adults' experiences of living with long-term musculoskeletal pain at home.European journal of ageing · 2021Article
- Chronic Conditions, Persistent Pain, and Psychological Distress Among the Rural Older Adults: A Path Analysis in Shandong, China.Frontiers in medicine · 2021Article
- Development and Psychometric Validation of a New Scale for Assessment and Screening of Frailty Among Older Indians.Clinical interventions in aging · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFrailty, a syndrome of physiological deficits, is prevalent among older adults and predicts elevated risk of adverse health outcomes. Although persistent pain predicts similar risk, it is seldom considered in frailty measurement. This article evaluated the construct and predictive validity of including persistent pain in phenotypic frailty measurement.
methodsFrailty and persistent pain were operationalized using data from the Health and Retirement Study (2006-2012 waves). Among a subset of adults aged 65 and older (n = 3,652), we used latent class analysis to categorize frailty status and to evaluate construct validity. Using Cox proportional hazards models, we compared time to incident adverse outcomes (death, fall, hospitalization, institutionalization, and functional disability) between frailty classes determined by either including or excluding persistent pain as a frailty component.
resultsIn latent class models, persistent pain occurred with other frailty components in patterns consistent with a medical syndrome. Frail and intermediately frail classes determined by including persistent pain were more strongly associated with all adverse outcomes compared with frail and intermediately frail classes determined excluding persistent pain. Frail respondents had significantly greater risk of death compared with nonfrail respondents when frailty models included rather than excluded persistent pain (respectively, hazard ratio [HR] = 3.87, 95% confidence interval [CI] = 2.99-5.00 (including pain); HR = 2.10, 95% CI = 1.71-2.59 (excluding pain).
conclusionsFindings support consideration of persistent pain as a component of the frailty phenotype. Persistent pain assessment may provide an expedient method to enhance frailty measurement and improve prediction of adverse outcomes.
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