ArticleDevelopment (Cambridge, England)2017
R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling.Developmental biology · 2025Article
- The role of the haematopoietic stem cell niche in development and ageing.Nature reviews. Molecular cell biology · 2025Review
- Molecular characterization of human HSPCs with different cell fates in vivo using single-cell transcriptome analysis and lentiviral barcoding technology.Clinical and translational medicine · 2024Article
- Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution.Nature communications · 2021Article
- Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis.Cell discovery · 2021Article
- Making Blood from the Vessel: Extrinsic and Environmental Cues Guiding the Endothelial-to-Hematopoietic Transition.Life (Basel, Switzerland) · 2021Review
- Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.Blood · 2020Article
- MicroRNA-525 enhances chondrosarcoma malignancy by targeting F-spondin 1.Oncology letters · 2019Article
- An optimised pipeline for parallel image-based quantification of gene expression and genotyping afterBiology open · 2018Article
- Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis.The Journal of experimental medicine · 2017Review
- The role of Wnt signaling in hematopoietic stem cell development.Critical reviews in biochemistry and molecular biology · 2017Review
- WNT16 primer.Differentiation; research in biological diversityArticle
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow transplants, but finding immune-compatible donors limits treatment availability and efficacy. Recapitulation of endogenous specification during development is a promising approach to directing HSC specification
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.