ArticleDevelopment (Cambridge, England)2017
Genome-wide identification of regulatory elements in Sertoli cells.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs.Nature structural & molecular biology · 2026Article
- Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation.Science advances · 2026Article
- The gene regulatory landscape driving mouse gonadal supporting cell differentiation.Science advances · 2025Article
- The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health.Frontiers in endocrinology · 2025Review
- Postnatal Ovarian Transdifferentiation in the Absence of Estrogen Receptor Signaling Is Dependent on Genetic Background.Endocrinology · 2024Article
- The single-cell chromatin landscape in gonadal cell lineage specification.BMC genomics · 2024Article
- FOXL2 interaction with different binding partners regulates the dynamics of ovarian development.Science advances · 2024Article
- Identification ofTranslational andrology and urology · 2023Article
- The single-cell chromatin accessibility landscape in mouse perinatal testis development.eLife · 2023Article
- In vitro cellular reprogramming to model gonad development and its disorders.Science advances · 2023Article
- Pervasive male-biased expression throughout the germline-specific regions of the sea lamprey genome supports key roles in sex differentiation and spermatogenesis.Communications biology · 2022Article
- Sex Maintenance in Mammals.Genes · 2021Review
- Cis-Regulatory Control of Mammalian Sex Determination.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- The Chromatin State during Gonadal Sex Determination.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation ofDevelopment (Cambridge, England) · 2020Article
- WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis.Reproduction (Cambridge, England) · 2019Review
- CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.PLoS genetics · 2019Article
- Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination.Developmental biology · 2019Article
- Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice.PloS one · 2019Article
- Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.Human molecular genetics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
A current goal of molecular biology is to identify transcriptional networks that regulate cell differentiation. However, identifying functional gene regulatory elements has been challenging in the context of developing tissues where material is limited and cell types are mixed. To identify regulatory sites during sex determination, we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and ChIP-seq for H3K27ac. DNaseI-seq identified putative regulatory sites around genes enriched in Sertoli and pregranulosa cells; however, active enhancers marked by H3K27ac were enriched proximal to only Sertoli-enriched genes. Sequence analysis identified putative binding sites of known and novel transcription factors likely controlling Sertoli cell differentiation. As a validation of this approach, we identified a novel Sertoli cell enhancer upstream of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.