Evidence map›Paper›PMID 28087565›Full record

ArticleDiabetes2017

Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.

Leo M Y Lee, Maran B W Leung, Rachel C Y Kwok, Yun Chung Leung, Chi Chiu Wang, Peter J McCaffery, Andrew J Copp, Alisa S W Shum

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Ontogeny of collective behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  3. Article
  4. Article
  5. Retinoid metabolism: new insights.Journal of molecular endocrinology · 2022
    Review
  6. Review
  7. Role of carotenoids and retinoids during heart development.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Leo M Y LeeSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Maran B W LeungSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Rachel C Y KwokSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Yun Chung LeungDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Chi Chiu WangSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Peter J McCafferyInstitute of Medical Sciences, University of Aberdeen, Aberdeen, U.K.
Andrew J CoppNewlife Birth Defects Research Centre, Institute of Child Health, University College London, London, U.K.
Alisa S W ShumSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong alisa-shum@cuhk.edu.hk.
Chinese University of Hong Kong · CNHong Kong Polytechnic University · HK

Funding

Wellcome Trust 087525
6 · The paper itself

Abstract

Pregestational diabetes is highly associated with an increased risk of birth defects. However, factors that can increase or reduce the expressivity and penetrance of malformations in pregnancies in women with diabetes remain poorly identified. All-

Indexed as

AnimalsCongenital AbnormalitiesDiabetes Mellitus, ExperimentalDown-RegulationEmbryonic DevelopmentFemaleGene-Environment InteractionGene Knockdown TechniquesHomeostasisMicePregnancyPregnancy in DiabeticsRetinoic Acid 4-HydroxylaseSignal TransductionTretinoinCyp26a1 protein, mouseRetinoic Acid 4-HydroxylaseTretinoin

Identifiers

PMID28087565
PMCPMC5365142
OpenAlexW2572977319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.