Evidence map›Paper›PMID 28087531›Full record

ArticleApplied and environmental microbiology2017

Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients.

Na Tian, Lina Faller, Daniel A Leffler, Ciaran P Kelly, Joshua Hansen, Jos A Bosch, Guoxian Wei, Bruce J Paster, Detlef Schuppan, Eva J Helmerhorst

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

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  18. Characterization ofFoods (Basel, Switzerland) · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Na TianDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.
Lina FallerThe Forsyth Institute, Department of Microbiology, Cambridge, Massachusetts, USA.
Daniel A LefflerCeliac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Ciaran P KellyCeliac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Joshua HansenCeliac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Jos A BoschDepartment of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Guoxian WeiDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.
Bruce J PasterThe Forsyth Institute, Department of Microbiology, Cambridge, Massachusetts, USA.
Detlef SchuppanCeliac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Eva J HelmerhorstDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA helmer@bu.edu.
Boston University · USHarvard University · USAcademic Medical Center · NLBeth Israel Deaconess Medical Center · USJohannes Gutenberg University Mainz · DE

Funding

Oral Microbial Biomarkers in Periodontal Disease ProgressionR01DE021565 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI PASTER, BRUCE J · 2010 to 2013
$2.9M
Gastro-intestinal microbes degrading dietary glutenR01AI087803 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HELMERHORST, EVA JOSEPHINE · 2010 to 2014
$2.0M
Oral microbial enzymes for the treatment of celiac diseaseK02AI101067 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HELMERHORST, EVA JOSEPHINE · 2013 to 2017
$509k
NIAID NIH HHS K02 AI101067NIAID NIH HHS R01 AI087803NIDCR NIH HHS R01 DE021565
6 · The paper itself

Abstract

Celiac disease (CD) is a chronic immune-mediated enteropathy induced by dietary gluten in genetically predisposed individuals. Saliva harbors the second highest bacterial load of the gastrointestinal (GI) tract after the colon. We hypothesized that enzymes produced by oral bacteria may be involved in gluten processing in the intestine and susceptibility to celiac disease. The aim of this study was to investigate salivary enzymatic activities and oral microbial profiles in healthy subjects versus patients with classical and refractory CD. Stimulated whole saliva was collected from patients with CD in remission (

Indexed as

SalivaAdultAgedBacterial LoadCeliac DiseaseFemaleGliadinGlutensHumansHydrolysisIntestinal MucosaLactobacillusMaleMicrobiotaMiddle AgedRNA, Ribosomal, 16SGliadinGlutensRNA, Ribosomal, 16S16S rRNAceliac diseaseenzymemicrobiomesaliva

Identifiers

PMID28087531
PMCPMC5335528
OpenAlexW2579820441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.