Evidence map›Paper›PMID 28086982›Full record

ArticleBreast cancer research : BCR2017

Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis.

Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Jill A McDonald and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
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  10. Epidemiology, early detection, and management of breast cancer in China: A comprehensive review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
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  19. A Comparison ofInorganica chimica acta · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Huiyan MaDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA. hma@coh.org.ORCID 0000-0002-3335-4775
Giske UrsinCancer Registry of Norway, Oslo, Norway.
Xinxin XuDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA.
Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Kayo TogawaDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA.
Lei DuanDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA.
Yani LuDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA.
Kathleen E MaloneDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Polly A MarchbanksDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Jill A McDonaldCollege of Health and Social Services, New Mexico State University, Las Cruces, NM, 88003, USA.
Michael S SimonKarmanos Cancer Institute, Department of Oncology, Wayne State University, Detroit, MI, 48201, USA.
Suzanne G FolgerDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Jane Sullivan-HalleyDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA.
Dennis M DeapenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Michael F PressPathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute, 1500 East Duarte Rd. Duarte, City of Hope, CA, 91010, USA.
City of Hope · USUniversity of Southern California · USCenters for Disease Control and Prevention · USFred Hutch Cancer Center · USNew Mexico State University · USUniversity of Oslo · NOWayne State University · US

Funding

USC CANCER EPIDEMIOLOGY &BIOSTATISTICS UNITP01CA017054 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI URSIN, GISKE · 1985 to 2009
$18.2M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067010 · PC · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROSS, RONALD K · 1996 to 2000
$2.4M
BRCA1, ORAL CONTRACEPTIVES, AND HORMONAL RISK FACTORSR01CA074847 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1999 to 2003
$1.3M
Research and Mentoring on Energetic Factors and Cancer: Established InvestigatorK05CA136967 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BERNSTEIN, LESLIE · 2009 to 2013
$684k
A pooled analysis for risk factors of triple negative breast cancerR03CA188549 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MA, HUIYAN · 2014 to 2015
$175k
SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS--SEERN01CN065064 · CN · WAYNE STATE UNIVERSITY · PI WEISS, LINDA K · 1996 to 1997
–
THE ROLE OF GESTURE AND SPEECH IN NARRATIONF32HD007022 · NICHD · UNIVERSITY OF CHICAGO · PI CHURCH, RUTH B · 1989 to 1989
–
NCI NIH HHS K05 CA136967NCI NIH HHS N01 CN065064NCI NIH HHS N01 PC035139NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA017054NCI NIH HHS R01 CA074847NCI NIH HHS R03 CA188549NICHD NIH HHS Y01 HD007022World Health Organization 001
6 · The paper itself

Abstract

backgroundEarly age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whether all of these are risk factors for triple-negative breast cancer (TNBC).

methodsWe evaluated the associations of these reproductive factors with TNBC, in 2658 patients with breast cancer (including 554 with TNBC) and 2448 controls aged 20-64 years, who participated in one of the three population-based case-control studies: the Women's Contraceptive and Reproductive Experiences Study, the Women's Breast Carcinoma in situ Study, or the Women's Learning the Influence of Family and Environment Study. We used multivariable polychotomous unconditional logistic regression methods to conduct case-control comparisons among breast cancer subtypes defined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression status.

resultsTNBC risk decreased with increasing duration of breastfeeding (P

conclusionsOur data indicate that breastfeeding decreases the risk of TNBC, especially for younger African-American women.

Indexed as

AdultBiomarkers, TumorBlack or African AmericanCase-Control StudiesErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedOdds RatioPopulation SurveillanceReceptors, EstrogenReceptors, ProgesteroneReproductive HistoryRisk AssessmentRisk FactorsTriple Negative Breast NeoplasmsBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, ProgesteroneAfrican-American womenBreastfeedingLuminal AReproductive factorsTriple-negative breast cancerWhite women

Identifiers

PMID28086982
PMCPMC5237290
OpenAlexW2575702899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.