ArticleVirology journal2017
Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma.
Article in Virology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility.Mediators of inflammation · 2018Pooled it
- Activation of the CCL22/CCR4 causing EMT process remodeling under EZH2-mediated epigenetic regulation in cervical carcinoma.Journal of Cancer · 2024Article
- Increase of the T-reg-recruiting chemokine CCL22 expression in a progressive course of cervical dysplasia.Journal of cancer research and clinical oncology · 2023Article
- TIME Is Ticking for Cervical Cancer.Biology · 2023Review
- Article
- Cervical Cancer Stem-Like Cell Transcriptome Profiles Predict Response to Chemoradiotherapy.Frontiers in oncology · 2021Article
- Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma.NPJ precision oncology · 2020Article
- Emerging Targets of Immunotherapy in Gynecologic Cancer.OncoTargets and therapy · 2020Review
- Multimodal Therapy is a Better Choice for Patients with Brain Metastasis from Cervical Cancer.Cancer management and research · 2020Article
- Higher CCL22+ Cell Infiltration is Associated with Poor Prognosis in Cervical Cancer Patients.Cancers · 2019Article
- Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer.Oncology reports · 2019Article
- Gene expression profiling informs HPV cervical histopathology but not recurrence/relapse after LEEP in ART-suppressed HIV+HPV+ women.Carcinogenesis · 2019Article
- Immunotherapy in Head and Neck Squamous Cell Cancer.Clinical and experimental otorhinolaryngology · 2018Article
- Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions.Papillomavirus research (Amsterdam, Netherlands) · 2018Review
- Cervical cancer metastasis to the brain: A case report and review of literature.Surgical neurology international · 2017Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe disequilibrium of local immune microenvironment is an essential element during tumorigenesis.
methodBy conducting real-time polymerase chain reaction, we identified the mRNA level of immune factors, FoxP3 (forkhead box protein P3), CCL22/CCR4 (chemokine (C-C motif) ligand 22/CC chemokine receptor 4), OX40L/OX40 (tumor necrosis factor superfamily member 4/tumor necrosis factor receptor superfamily member 4) and Smad3 (SMAD family member 3) in neoplastic foci and its periphery tissues from 30 cases of squamous cervical carcinoma and 20 cases of normal cervix.
resultThe FoxP3, CCL22 and CCR4 mRNA level in local immune microenvironment of normal cervix was lower than that in cervical cancer. While OX40L, OX40 and Smad3 mRNA level profile in normal cervix was higher than that in cervical cancer. Beyond individual effect, the pairwise positive correlations were demonstrated among the mRNA level of FoxP3, CCL22 and CCR4. The mRNA level of OX40 negatively correlated with CCL22, but positively correlated with Smad3. Moreover, the mRNA level of FoxP3 and CCL22 was increased while Smad3 was decreased in cervical tissue with HPV (human papilloma virus) infection.
conclusionOur data yields insight into the roles of these immune factors in cervical carcinogenesis. It may therefore be that, in microenvironment of cervical squamous cell carcinoma, along with the context of HPV infection, negative immune regulators FoxP3, CCL22 and CCR4 might overwhelm positive immune factors OX40L, OX40 and Smad3, giving rise to an immunosuppressive status and promote the progression of cervical carcinogenesis.
trial registrationNot applicable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.