ArticleBMC surgery2017
Postoperative fluid overload is a risk factor for adverse surgical outcome in patients undergoing esophagectomy for esophageal cancer: a retrospective study in 335 patients.
Article in BMC surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Effect of perioperative goal-directed fluid therapy on postoperative complications after thoracic surgery with one-lung ventilation: a systematic review and meta-analysis.World journal of surgical oncology · 2023Pooled it
- Institutional modified post esophagectomy care protocol offers improved perioperative outcomes - a single-center propensity score matched analysis.World journal of surgical oncology · 2026Article
- Association of perioperative patient characteristics, intraoperative fluid management, and vasopressors with anastomotic leakage after Ivor-Lewis esophagectomy-a single center retrospective cohort.Surgical endoscopy · 2026Article
- Early Extubation After Thoracic Esophagectomy Restricts Fluid Overload and Prevents Pulmonary Complications and Surgical Site Infections: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Impact of intraoperative fluid therapy on postoperative complications following robotic-assisted minimally invasive esophagectomy (RAMIE).BMC anesthesiology · 2025Article
- Effect of perioperative fluid balance on the postoperative outcomes of patient after esophagectomy.Bioinformation · 2025Article
- Quantifying fluid retention following modern pain management in TKA: an observational study.Knee surgery & related research · 2024Article
- Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients.Journal of clinical monitoring and computing · 2024Article
- Impact of intraoperative fluid management on postoperative complications in patients undergoing minimally invasive esophagectomy for esophageal cancer: a retrospective single-center study.BMC anesthesiology · 2024Article
- Impact of fluid balance and opioid-sparing anesthesia within enchanced recovery pathway on postoperative morbidity after transthoracic esophagectomy for cancer.Frontiers in medicine · 2024Article
- Impact of Enhanced Recovery Protocols on Short-Term Outcomes in Esophagectomy: A Retrospective Cohort Study from Cancer Research Institute, Uttarakhand, India.World journal of surgery · 2023Article
- The impact of intraoperative and postoperative fluid balance on complications for transthoracic esophagectomy: a retrospective analysis.BMC research notes · 2023Article
- Fluid balance following laparotomy for hollow viscus perforation: A study of morbidity and mortality.Surgery in practice and science · 2023Article
- The Impact of Perioperative Fluid Balance on Postoperative Complications after Esophagectomy for Esophageal Cancer.Journal of clinical medicine · 2022Article
- A cost-effectiveness modeling study of treatment interventions for stage I to III esophageal squamous cell carcinoma.Cost effectiveness and resource allocation : C/E · 2022Article
- [Perioperative fluid management in major abdominal surgery].Der Anaesthesist · 2021Review
- Postoperative outcomes based on crystalloid administration in pediatric patients with necrotizing enterocolitis undergoing laparotomy.Medicine · 2020Observational
- The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection.Surgery today · 2020Review
- Fluid management in perioperative and critically ill patients.Acute and critical care · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRestrictive intraoperative fluid management is increasingly recommended for patients undergoing esophagectomy. Controversy still exists about the impact of postoperative fluid management on perioperative outcome.
methodsWe retrospectively examined 335 patients who had undergone esophagectomy for esophageal cancer at the University Hospital Freiburg between 1996 and 2014 to investigate the relation between intra- and postoperative fluid management and postoperative morbidity after esophagectomy.
resultsPerioperative morbidity was 75%, the in-hospital mortality 8%. A fluid balance above average on the operation day was strongly associated with a higher rate of postoperative mortality (21% vs 3%, p < 0.001) and morbidity (83% vs 66%, p = 0.001). Univariate analysis for risk factors for adverse surgical outcome (Clavien ≥ III) identified ASA-score (p = 0.002), smoking (p = 0.036), reconstruction by colonic interposition (p = 0.036), cervical anastomosis (p = 0.017), blood transfusion (p = 0.038) and total fluid balance on the operation day and on POD 4 (p = 0.001) as risk factors. Multivariate analysis confirmed only ASA-score (p = 0.001) and total fluid balance (p = 0.001) as independent predictors of adverse surgical outcome.
conclusionIntra- and postoperative fluid overload is strongly associated with increased postoperative morbidity. Our results suggest restrictive intra- and especially postoperative fluid management to optimize the outcome after esophagectomy.
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