ArticleMalaria journal2017
In vivo antiplasmodial activity and toxicological assessment of hydroethanolic crude extract of Ajuga remota.
Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 78 citations in OpenAlex.
- Evaluation of in vitro and in vivo antidiabetic potential of hydromethanol extract and solvent fraction of the leaves ofMetabolism open · 2026Article
- Antiplasmodial and immunomodulatory activities of dichloromethane extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment.BMC chemistry · 2025Article
- In vivo Antimalarial and Liver Function Profiles of Methanol Extract ofEthiopian journal of health sciences · 2024Article
- Nephroprotective Effect of the Leaf Extract ofJournal of experimental pharmacology · 2024Article
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- In vitro antiplasmodial activity and toxicological profile of extracts, fractions and chemical constituents of leaves and stem bark from Dacryodes edulis (Burseraceae).BMC complementary medicine and therapies · 2023Article
- Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria.BMC complementary medicine and therapies · 2023Article
- A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score.Malaria journal · 2023Review
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- Anti-Convulsant Activity of Soxhlet Leaf Extracts ofJournal of experimental pharmacology · 2023Article
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- Antimalarial Properties ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Ethnobotanical study of medicinal plants used by the people of Mosop, Nandi County in Kenya.Frontiers in pharmacology · 2023Article
- Antimalarial and immunomodulatory potential of chalcone derivatives in experimental model of malaria.BMC complementary medicine and therapies · 2022Article
- Article
- Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies.Malaria journal · 2022Review
- Assessment of antimalarial medicinal plants used in Nigerian ethnomedicine reveals antimalarial potential ofHeliyon · 2022Article
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- Synthesis, antiplasmodial activity and in silico molecular docking study of pinocembrin and its analogs.BMC chemistry · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria is one of the most life-threatening health problems worldwide and treatment has been compromised by drug resistance. Identifying lead molecules from natural products might help to find better anti-malarial drugs, since those obtained from natural sources are still effective against malarial parasites. This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models.
methodsIn vivo parasite growth inhibitory effect of crude extract was assessed in mice inoculated with Plasmodium berghei (ANKA strain). The in vivo antiplasmodial activity of the test extract was performed against early infection (4-day suppressive test), curative effect against established infection and prophylactic effect against residual infection. Acute and sub-acute toxicity were carried out according to OECD guidelines.
resultsIn vivo parasite growth inhibition effect of hydroethanolic crude extract of A. remota was evaluated at 30, 50 and 100 mg/kg dose levels. It suppressed parasitaemia by 77.34% at 100 mg/kg dose level in the 4-day test. In curative and prophylactic potential tests, it suppressed parasitaemia by 66.67 and 59.66% at 100 mg/kg dose level, respectively. In vivo toxicity tests revealed no toxicity. All parasitaemia suppressions were statistically significant at P < 0.05 as compared to the vehicle-treated group. The crude extract also prolonged survival time in a dose dependent manner.
conclusionsThe investigation results suggest that the leave extract of Ajuga remota possesses antimalarial activity.
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