Evidence map›Paper›PMID 28086100›Full record

ArticleCell2017

The Interfaces of Genetic Conflict Are Hot Spots for Innovation.

Joshua Carter, Connor Hoffman, Blake Wiedenheft

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. How bacteria control the CRISPR-Cas arsenal.Current opinion in microbiology · 2018
    Review
  3. Protein Inhibitors of CRISPR-Cas9.ACS chemical biology · 2018
    Review
  4. CRISPR/Cas9: A Potential Life-Saving Tool. What's next?Molecular therapy. Nucleic acids · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joshua CarterDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Connor HoffmanDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Blake WiedenheftDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: bwiedenheft@gmail.com.
Montana State University · US

Funding

Structure and function of CRISPR RNA-guided foreign DNA surveillance systems in P. aeruginosaR01GM110270 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI WIEDENHEFT, BLAKE A · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM110270
6 · The paper itself

Abstract

RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for the Cas9 scalpel.

Indexed as

RNABacteriaCRISPR-Cas SystemsDNAEndonucleasesGenetic EngineeringDNAEndonucleasesRNA

Identifiers

PMID28086100
PMCPMC5480287
OpenAlexW2577635297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.