Evidence map›Paper›PMID 28086095›Full record

ArticleCell2017

Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala.

Wenfei Han, Luis A Tellez, Miguel J Rangel, Simone C Motta, Xiaobing Zhang, Isaac O Perez, Newton S Canteras, Sara J Shammah-Lagnado, Anthony N van den Pol, Ivan E de Araujo

Open access · bronzeAbstract read
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 297 citations in OpenAlex.

  1. Article
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  9. Genetic therapies for neurological diseases.Pharmacological reviews · 2026
    Review
  10. Trigeminal Motor Nucleus Regulates Microstructure of Feeding Behavior without Affecting Total Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Article
  13. A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Wenfei HanThe John B Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA; School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China.
Luis A TellezThe John B Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
Miguel J RangelThe John B Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA; Department of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508, Brazil.
Simone C MottaDepartment of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508, Brazil.
Xiaobing ZhangDepartment of Neurosurgery, Yale University School of Medicine, New Haven, CT 06519, USA.
Isaac O PerezThe John B Pierce Laboratory, New Haven, CT 06519, USA.
Newton S CanterasDepartment of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508, Brazil.
Sara J Shammah-LagnadoDepartment of Physiology and Biophysics, Biomedical Sciences Institute, University of São Paulo, São Paulo 05403, Brazil.
Anthony N van den PolDepartment of Neurosurgery, Yale University School of Medicine, New Haven, CT 06519, USA.
Ivan E de AraujoThe John B Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: iaraujo@jbpierce.org.
Universidade de São Paulo · BRYale University · USJohn B. Pierce Laboratory · USTongji University · CN

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Response properties of hypothalamic MCH neuronsR01NS048476 · NINDS · YALE UNIVERSITY · PI VAN DEN POL, ANTHONY N · 2005 to 2014
$3.7M
(PQA3) The gut-brain axis: a novel target for treating behavioral alterations inR01CA180030 · NCI · JOHN B. PIERCE LABORATORY, INC. · PI DE ARAUJO, IVAN E, SMALL, DANA M · 2013 to 2016
$2.6M
Dopamine Excites Orexigenic AgRP/NPY Neurons, but Inhibits Anorexic POMC NeuronsR01DK103176 · NIDDK · YALE UNIVERSITY · PI VAN DEN POL, ANTHONY N · 2015 to 2019
$1.9M
Neural circuitry of sweet tasteR01DC014859 · NIDCD · JOHN B. PIERCE LABORATORY, INC. · PI DE ARAUJO, IVAN E · 2015 to 2019
$1.5M
Arcuate Nucleus Glutamatergic Neurons Modulate Energy HomeostasisR01DK084052 · NIDDK · YALE UNIVERSITY · PI VAN DEN POL, ANTHONY N · 2010 to 2013
$1.4M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA180030NIDCD NIH HHS R01 DC014859NIDDK NIH HHS R01 DK084052NIDDK NIH HHS R01 DK103176NINDS NIH HHS R01 NS048476
6 · The paper itself

Abstract

Superior predatory skills led to the evolutionary triumph of jawed vertebrates. However, the mechanisms by which the vertebrate brain controls predation remain largely unknown. Here, we reveal a critical role for the central nucleus of the amygdala in predatory hunting. Both optogenetic and chemogenetic stimulation of central amygdala of mice elicited predatory-like attacks upon both insect and artificial prey. Coordinated control of cervical and mandibular musculatures, which is necessary for accurately positioning lethal bites on prey, was mediated by a central amygdala projection to the reticular formation in the brainstem. In contrast, prey pursuit was mediated by projections to the midbrain periaqueductal gray matter. Targeted lesions to these two pathways separately disrupted biting attacks upon prey versus the initiation of prey pursuit. Our findings delineate a neural network that integrates distinct behavioral modules and suggest that central amygdala neurons instruct predatory hunting across jawed vertebrates.

Indexed as

Predatory BehaviorAnimalsAnxietyCentral Amygdaloid NucleusElectromyographyInterneuronsMandibleMiceNeckNeuronsPeriaqueductal Graycentral amygdalacraniofacial controljawlocomotionmotor controlperiaqueductal greypredationpredatory huntingreticular formation

Identifiers

PMID28086095
PMCPMC5278763
OpenAlexW2578245286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.